Aprovel Tablet 300mg

About Aprovel Tablet 300mg

Aprovel Tablet 300mg Uses

• Treats high blood pressure (hypertension) in adults.
• Protects the kidneys in people with type 2 diabetes and early to moderate kidney disease.
• Used alone or combined with other blood pressure lowering medicines for better control.
• Helps reduce long term strain on the heart caused by persistently high blood pressure.

Aprovel Tablet 300mg Benefits

• Provides steady 24 hour blood pressure control with a single daily dose.
• Slows the decline in kidney function in diabetic patients with protein in urine.
• Does not typically cause the dry cough associated with ACE inhibitor medicines.
• Available in a higher 300mg strength for patients needing stronger blood pressure control.

Aprovel Tablet 300mg Dosage

• The usual maintenance dose for hypertension is 150mg to 300mg once daily.
• Doctors may start at a lower strength and increase to 300mg based on response.
• For diabetic kidney disease, 300mg once daily is the typical target dose.
• Should be taken at the same time every day, with or without food.

What Experts Say

Irbesartan is an angiotensin II receptor blocker that prevents angiotensin II from binding to its receptor in blood vessel walls. This blocks the hormone's constricting effect, allowing blood vessels to relax and blood pressure to fall over the course of steady daily use.

Physicians in Pakistan often reserve the 300mg strength for patients who need stronger blood pressure control or who have diabetic kidney disease, since clinical trial evidence specifically supports this dose for slowing the progression of protein loss in urine. Lower strengths are usually tried first in most newly diagnosed patients before stepping up the dose.

Kidney function and blood potassium are usually checked before starting irbesartan and periodically during treatment, since ARBs can raise potassium levels and affect kidney filtration in susceptible patients. Regular blood pressure monitoring alongside these lab checks guides any further dose adjustments over time.

Drug Class

• Angiotensin II receptor blocker (ARB)

Aprovel Tablet 300mg formula

• Irbesartan

Available forms

• Tablet

How to use Aprovel Tablet 300mg?

• Take Aprovel Tablet 300mg once daily at the same time, as directed by your doctor.
• Swallow the tablet whole with water, with or without food.
• Do not stop the medicine suddenly even if you feel well.
• Monitor your blood pressure regularly during treatment.
• Inform your doctor if you become pregnant while taking this medicine.

Drug Interactions

• Potassium sparing diuretics: Combined use can raise blood potassium to unsafe levels.
• NSAIDs like ibuprofen: Can reduce the blood pressure lowering effect and affect kidney function.
• Lithium: Blood levels of lithium can rise, increasing the risk of toxicity.
• ACE inhibitors: Combining with irbesartan raises the risk of high potassium and reduced kidney function.
• Other antihypertensives: May increase the risk of excessively low blood pressure.

Risks and warnings

• Pregnancy: Can cause serious harm to an unborn baby and should be stopped as soon as pregnancy is confirmed.
• Kidney artery narrowing: People with narrowed arteries to the kidneys need close monitoring since kidney function can worsen.
• High potassium levels: Should be used cautiously in people with kidney disease or those on potassium supplements.
• Dehydration or low blood volume: Can lead to a sharp drop in blood pressure at treatment start.
• Severe liver disease: Limited data is available, so use requires medical judgment.

Aprovel Tablet 300mg Side Effects

• Dizziness
• Fatigue
• Nausea
• Low blood pressure symptoms like lightheadedness
• Raised blood potassium levels
• Muscle cramps
• Mild swelling in the hands or feet

Storage Conditions

• Store below 30°C in a cool, dry place away from direct sunlight.
• Keep the tablets in their original pack until ready to use.
• Do not store in a humid bathroom cabinet.
• Keep out of reach of children.