Arti DS Tablet 40mg / 240mg

About Arti DS Tablet 40mg / 240mg

Arti DS Tablet 40mg / 240mg Uses

• Uncomplicated Plasmodium falciparum malaria
• Malaria in adults and children weighing above 35kg
• Mixed malaria infections involving falciparum species

Arti DS Tablet 40mg / 240mg Benefits

• Combines two antimalarials for a stronger combined effect
• Higher double strength dose means fewer tablets per course
• Clears malaria parasites quickly from the bloodstream
• Reduces the chance of drug resistance developing

What Experts Say

Artemether acts quickly against malaria parasites in the blood, while lumefantrine works more slowly and clears any parasites artemether leaves behind. Combining the two reduces the chance that surviving parasites develop resistance to either drug alone. This is why fixed dose combinations are now the standard treatment for falciparum malaria.

The double strength formula packs 40mg of artemether and 240mg of lumefantrine into each tablet, compared to the standard 20mg and 120mg strength. This means adults and larger patients need fewer tablets to complete a full treatment course, which can improve how consistently the full course is taken.

Lumefantrine absorbs better when taken with fatty food, so timing meals around each dose matters for how well the treatment works. Both components can affect heart rhythm at high doses, so this combination is generally avoided in patients with known cardiac rhythm problems.

Drug Class

• Antimalarial combination
• Artemisinin-based combination therapy (ACT)

Arti DS Tablet 40mg / 240mg formula

• Artemether + Lumefantrine

Available forms

• Tablet

How to use Arti DS Tablet 40mg / 240mg?

• Take with fatty food or milk to improve absorption
• Complete the full course even if symptoms improve early
• Usual course is taken twice daily for three days as directed
• Do not double the dose if a dose is missed

Drug Interactions

• CYP3A4 Inhibitors: Drugs like ketoconazole can raise artemether-lumefantrine levels.
• Other QT-Prolonging Drugs: Combining with certain antibiotics or antiarrhythmics raises heart rhythm risk.
• Mefloquine or Quinine: Avoid taking together with other antimalarials unless directed by a doctor.
• Grapefruit Juice: May increase drug levels and should be avoided during treatment.

Risks and warnings

• Heart Rhythm Disorders: Avoid in patients with known QT prolongation or irregular heartbeat.
• Pregnancy: Use in the first trimester only if clearly necessary and advised by a doctor.
• Liver Disease: Use with caution and monitor liver function.
• Incomplete Course: Stopping early increases the risk of malaria relapse and resistance.

Arti DS Tablet 40mg / 240mg Side Effects

• Headache
• Dizziness
• Loss of appetite
• Nausea and vomiting
• Abdominal pain
• Sleep disturbance
• Joint and muscle pain

Storage Conditions

• Store below 30°C in a dry place
• Protect from moisture and direct sunlight
• Keep the blister strip sealed until each dose is due
• Keep out of reach of children