Beflam Tablet 75mg

About Beflam Tablet 75mg

Beflam Tablet Uses

• Rheumatoid arthritis, including joint pain, swelling, and morning stiffness.
• Osteoarthritis, including pain and reduced mobility in the knees, hips, and hands.
• Ankylosing spondylitis affecting the spine and sacroiliac joints.
• Acute gout attacks causing sudden severe joint pain and swelling.
• Periarthritis including frozen shoulder, tendinitis, and bursitis.
• Acute musculoskeletal disorders including sprains, strains, and fractures.
• Low back pain and lumbosciatica.
• Post-operative and post-traumatic pain and swelling.
• Dental pain and oral surgical pain.
• Menstrual cramps (primary dysmenorrhea).
• Migraine headaches.

Beflam Tablet Benefits

• Diclofenac Potassium is faster-acting than Diclofenac Sodium due to its superior water solubility and more rapid gastrointestinal absorption, making Beflam well suited for acute pain.
• Effective for both inflammatory pain (arthritis, gout) and non-inflammatory pain (muscle strain, dental pain) in a single medicine.
• Provides relief within 30 to 60 minutes of taking the dose, faster than many other oral NSAIDs.
• Available at a lower price point than branded NSAID alternatives, making it accessible for long-term management of chronic conditions.
• Once or twice-daily dosing at 75mg simplifies treatment compared to three-times-daily regimens required by 50mg formulations.

What Experts Say

Beflam contains Diclofenac Potassium, one of the most widely prescribed NSAIDs globally, with a well-established clinical profile across arthritis, acute pain, and gynaecological conditions.

How It Works

Diclofenac inhibits both COX-1 and COX-2 cyclooxygenase enzymes, which are responsible for converting arachidonic acid into prostaglandins. Prostaglandins are the primary chemical mediators of pain, swelling, and fever at sites of injury or inflammation.

By reducing prostaglandin synthesis, Diclofenac decreases peripheral sensitization of pain receptors, reduces vascular permeability causing swelling, and lowers elevated body temperature.

Potassium Salt Advantage

Beflam uses the potassium salt of Diclofenac rather than the sodium salt. Diclofenac Potassium has significantly faster absorption from the gastrointestinal tract, reaching peak plasma concentration within 1 hour compared to 2 hours for Diclofenac Sodium.

This faster onset makes Beflam more suitable for acute pain conditions where rapid relief is the priority, such as dental pain, menstrual cramps, and migraine headache.

Clinical Note

Both FDA and EMA class warnings on cardiovascular and gastrointestinal risk apply to all Diclofenac formulations. The lowest effective dose for the shortest duration should always be used.

Elderly patients, those with a history of GI ulcers, and those on concurrent anticoagulants are at significantly higher risk of serious adverse events and should use Beflam only under close medical supervision.

Drug Class

• Non-Steroidal Anti-Inflammatory Drug (NSAID).
• Phenylacetic Acid Derivative.

Packaging and Quantity

• 1 pack contains 20 sugar-coated tablets.
• Packaged as 2 strips of 10 tablets each.

When Not to Use Beflam

• Known allergy or hypersensitivity to Diclofenac, Aspirin, or any other NSAID.
• Active stomach or duodenal ulcers, or a history of gastrointestinal bleeding.
• History of heart attack, stroke, or heart bypass surgery.
• Severe liver, kidney, or heart failure.
• Third trimester of pregnancy.
• Aspirin triad: patients with asthma, nasal polyps, and aspirin intolerance.

Beflam Tablet 75mg formula

• Diclofenac potassium

Available forms

• Tablets

How to use Beflam Tablet 75mg?

• Beflam should be taken with food or immediately after a meal to minimize the risk of stomach irritation.
• The tablet should be swallowed whole with a full glass of water. It should not be crushed or chewed.
• Alcohol should be avoided during treatment as it increases the risk of gastrointestinal bleeding.
• A doctor should be informed immediately if black or tarry stools, stomach pain, or vomiting blood occurs.
• The standard adult dose is 75mg once or twice daily, not exceeding 150mg per day as directed by the doctor.
• The dose should not be increased or treatment extended beyond the prescribed period without consulting a doctor.

Drug Interactions

All current medicines, supplements, and herbal products should be disclosed to the prescribing doctor before starting Beflam. Key interactions include:

• Anticoagulants such as warfarin: Diclofenac inhibits platelet aggregation and may enhance anticoagulant effects, significantly increasing bleeding risk. INR monitoring is essential.
• Aspirin and other NSAIDs: combining two NSAIDs provides no additional benefit and substantially raises the risk of gastrointestinal ulcers and bleeding.
• ACE inhibitors and ARBs: concurrent use reduces their antihypertensive effect and increases the risk of acute kidney injury.
• Diuretics: Diclofenac may reduce the effectiveness of diuretics and increase the risk of kidney impairment when used together.
• Lithium: Diclofenac reduces kidney clearance of lithium, raising blood levels and the risk of toxicity.
• Methotrexate: Diclofenac reduces kidney clearance of methotrexate, raising the risk of serious methotrexate toxicity.
• SSRIs such as fluoxetine and sertraline: concurrent use increases the risk of gastrointestinal bleeding.
• Cyclosporine: Diclofenac may increase cyclosporine nephrotoxicity.
• Corticosteroids: concurrent use substantially raises the risk of gastrointestinal ulcers and bleeding.

Risks and warnings

• Cardiovascular risk: All NSAIDs including Diclofenac carry an increased risk of serious cardiovascular events including heart attack and stroke. This risk is higher with long-term use and in patients with existing cardiovascular disease.
• Gastrointestinal risk: Beflam can cause gastrointestinal ulcers, bleeding, and perforation, which can be fatal. The risk is higher in patients above 65, those with a history of ulcers, and those on concurrent anticoagulants or corticosteroids.
• Kidney disease: Long-term use can reduce blood flow to the kidneys and impair function. Patients with existing kidney disease should use the lowest effective dose under close monitoring.
• Liver disease: Diclofenac is metabolized by the liver and has been associated with hepatotoxicity. Liver enzymes should be monitored in patients on long-term therapy.
• Pregnancy: Beflam is contraindicated in the third trimester. Use in the first and second trimesters should only occur under direct medical supervision.
• Breastfeeding: Diclofenac passes into breast milk in small amounts. A doctor should be consulted before use during breastfeeding.
• Asthma: Beflam can trigger or worsen asthma attacks, particularly in patients with aspirin-sensitive asthma. It should be stopped immediately if breathing worsens.
• Elderly patients: The risk of serious GI bleeding, kidney impairment, and cardiovascular events is significantly higher in patients above 65. The lowest effective dose should always be used.
• Driving and machinery: Beflam may cause dizziness. Caution is advised when driving or operating heavy machinery.

Beflam Tablet Side Effects

Most patients tolerate Beflam well at the recommended dose. Side effects are more common at higher doses and with prolonged use.

• Nausea or mild stomach discomfort.
• Acid reflux or heartburn.
• Diarrhea or constipation.
• Headache or dizziness.
• Mild ankle swelling due to fluid retention.
• Skin rash or itching.
• Elevated liver enzymes on blood tests, usually without symptoms.

Serious side effects are rare but require immediate medical attention:

• Black or tarry stools, vomiting blood, or severe abdominal pain, which may indicate gastrointestinal bleeding.
• Chest pain, shortness of breath, or sudden weakness on one side of the body, which may indicate a cardiovascular event.
• Significant reduction in urination or unusual swelling, which may indicate kidney damage.
• Yellowing of the skin or eyes, which may indicate liver damage.
• Severe allergic reaction including facial swelling, difficulty breathing, or widespread rash.
• Worsening asthma symptoms after taking Beflam.

Storage Conditions

• Store at room temperature, at 25°C.
• Keep away from direct sunlight, heat, and moisture.
• Store in the original packaging to protect from humidity.
• Keep out of reach and sight of children.
• Do not use after the expiry date printed on the packaging.
• Do not store in the bathroom or near a kitchen sink.