Bozpah Tablet 62.5mg

About Bozpah Tablet 62.5mg

Bozpah Tablet 62.5mg Uses

• Pulmonary arterial hypertension (WHO functional class II and III)
• Reducing new digital ulcers in systemic sclerosis with ongoing ulcer disease

Bozpah Tablet 62.5mg Benefits

• Improves exercise capacity in pulmonary hypertension
• Reduces pulmonary vascular resistance
• Slows worsening of symptoms and delays clinical decline
• Lowers the rate of new digital ulcer formation in scleroderma

What Experts Say

Bosentan works by blocking endothelin receptors, reversing the blood vessel narrowing that drives pulmonary arterial hypertension. This lowers pressure in the lung arteries, reduces the workload on the right side of the heart, and can improve how far a patient can walk without breathlessness.

Specialists usually start at a lower dose for the first four weeks before increasing it to the full maintenance dose, since a gradual increase reduces the chance of significant liver enzyme elevation. Regular monthly liver function testing is a standard, non-negotiable part of therapy for as long as treatment continues.

Because pulmonary hypertension is often diagnosed late, once symptoms like breathlessness, fatigue or ankle swelling are already present, physicians stress early referral to a cardiologist or pulmonologist for proper diagnostic workup and staging before starting therapy.

Drug Class

• Endothelin Receptor Antagonist

Bozpah Tablet 62.5mg formula

• Bosentan Monohydrate

Available forms

• Tablet

How to use Bozpah Tablet 62.5mg?

• Take one tablet in the morning and one in the evening, exactly as prescribed.
• Swallow the tablet whole with water, with or without food.
• Do not stop the tablet suddenly without your doctor's advice.
• Attend all scheduled liver function and blood tests during treatment.
• Use reliable contraception throughout treatment if you can become pregnant.

Drug Interactions

• Cyclosporine: Should not be combined, as it raises Bosentan levels significantly.
• Glyburide: Combined use increases the risk of liver toxicity and reduces blood sugar control.
• Hormonal Contraceptives: Bosentan can reduce their effectiveness, so a backup method is advised.
• Ketoconazole and Rifampicin: Change Bosentan blood levels significantly and need dose review.
• Warfarin: May need closer monitoring of blood clotting levels.

Risks and warnings

• Liver Toxicity: Can raise liver enzymes, so liver function tests are required before starting and monthly during treatment.
• Pregnancy Risk: Can cause serious birth defects, so effective contraception is required for women of childbearing age.
• Fluid Retention: May cause swelling in the legs or fluid buildup, particularly in the first months of treatment.
• Low Blood Count: Can lower hemoglobin, so blood counts are checked periodically.
• Fertility: May reduce sperm count in men using it long term.

Bozpah Tablet 62.5mg Side Effects

• Headache
• Flushing of the face
• Swelling in the legs or ankles
• Liver enzyme elevation
• Low hemoglobin (anemia)
• Nasal congestion
• Palpitations

Storage Conditions

• Store below 30°C, away from direct heat and sunlight.
• Keep in the original blister pack until ready to use.
• Protect from moisture.
• Keep out of reach of children.