Bravo Tablet 75mg / 0.2mg

About Bravo Tablet 75mg / 0.2mg

Bravo Tablet Uses

• Osteoarthritis joint pain
• Rheumatoid arthritis
• Ankylosing spondylitis
• Chronic back pain with inflammation
• Long term NSAID therapy in patients at ulcer risk

Bravo Tablet Benefits

• Reduces joint swelling and stiffness
• Eases movement in arthritic joints
• Lowers the risk of stomach ulcers linked to NSAID use
• Suits patients who need extended NSAID therapy
• Combines pain relief with gastric protection in one tablet

What Experts Say

Diclofenac sodium works by blocking cyclooxygenase enzymes that produce prostaglandins responsible for pain, swelling and fever. This makes it effective for chronic joint conditions like osteoarthritis and rheumatoid arthritis, though the same action thins the stomach lining and raises ulcer risk with prolonged use.

Misoprostol is added to counter this gastric risk. It is a synthetic prostaglandin E1 analogue that restores mucosal protection and reduces stomach acid secretion, helping prevent NSAID induced gastric and duodenal ulcers. Guidelines recommend this pairing for patients needing long term NSAID therapy who face higher gastrointestinal bleeding risk, including older adults and those with a prior ulcer history.

Because misoprostol stimulates uterine contractions, this combination is strictly avoided in pregnancy and in women who could become pregnant without reliable contraception. Physicians in Pakistan generally reserve this fixed dose combination for confirmed inflammatory joint disease, with dosing adjusted for kidney function, age and cardiovascular risk.

Drug Class

• NSAID and Prostaglandin Analogue Combination

Bravo Tablet 75mg / 0.2mg formula

• Diclofenac Sodium + Misoprostol

Available forms

• Tablet 75mg / 0.2mg

How to use Bravo Tablet 75mg / 0.2mg?

• This tablet works best when swallowed whole with a full glass of water
• Food or a meal alongside each dose helps reduce stomach upset
• The enteric coating should stay intact, so the tablet should not be crushed, split or chewed
• A fixed daily schedule, as advised by the doctor, helps maintain steady drug levels
• The prescribed dose and duration should never be changed without medical advice

Drug Interactions

• Aspirin and other NSAIDs: This combination raises the risk of stomach bleeding and ulcers.
• Blood thinners like Warfarin: Diclofenac can increase bleeding risk when taken with anticoagulants.
• ACE inhibitors and ARBs: This combination can reduce blood pressure control and affect kidney function.
• Diuretics: Diclofenac can reduce the effectiveness of water pills and strain the kidneys.
• Lithium: Diclofenac can raise lithium levels in the blood, increasing toxicity risk.
• Methotrexate: NSAIDs can increase methotrexate levels and related toxicity.
• Corticosteroids: Combined use raises the risk of gastrointestinal ulcers and bleeding.
• SSRIs: This combination can further increase bleeding risk.

Risks and warnings

• Pregnancy: Misoprostol can cause uterine contractions and miscarriage, so this tablet is strictly contraindicated in pregnant women and in women trying to conceive.
• Breastfeeding: Both components pass into breast milk, so this medicine is not recommended during breastfeeding unless a doctor advises otherwise.
• Cardiovascular risk: Diclofenac can raise the risk of heart attack and stroke, particularly with long term or high dose use.
• Gastrointestinal bleeding: Despite the added gastric protection, serious stomach bleeding or perforation can still occur, especially in older adults.
• Kidney impairment: Patients with reduced kidney function need dose adjustment or close monitoring.
• Liver disease: Existing liver problems call for caution, since diclofenac is processed by the liver.
• Asthma history: Patients with NSAID sensitive asthma or aspirin allergy may develop a severe allergic reaction.

Bravo Tablet Side Effects

• Stomach pain or cramping
• Diarrhea
• Nausea and vomiting
• Indigestion or heartburn
• Headache
• Dizziness
• Gastrointestinal bleeding or black stools
• Severe allergic reaction with swelling or difficulty breathing
• Signs of liver problems such as yellowing of the skin or eyes
• Sudden chest pain or shortness of breath
• Unusual vaginal bleeding or cramping in women

Storage Conditions

• Store below 30 degrees Celsius in a cool dry place
• Keep the strip in its original packaging away from light
• Protect from moisture and humidity
• Keep out of reach of children
• Discard any tablets past the printed expiry date