Chloroquine Phosphate Injection 200mg/5ml

About Chloroquine Phosphate Injection 200mg/5ml

Chloroquine Phosphate Injection 200mg/5ml Uses

• Treats acute attacks of malaria caused by Plasmodium vivax, Plasmodium ovale, Plasmodium malariae and susceptible strains of Plasmodium falciparum.
• Given in a hospital or clinic when a patient cannot take oral chloroquine due to severe vomiting or unconsciousness.
• Used for extraintestinal amoebic hepatitis when oral treatment options are not tolerated.

Chloroquine Phosphate Injection 200mg/5ml Benefits

• Works quickly to clear malaria parasites from the blood in severe cases.
• Injectable form ensures the full dose reaches the body when oral intake is not possible.
• Helps prevent uncomplicated malaria from progressing to complications like cerebral malaria.

What Experts Say

Doctors across Pakistan still rely on chloroquine phosphate injection for malaria cases where a patient cannot swallow tablets safely. Pakistan carries a real malaria burden, especially during and after the monsoon season, and vivax malaria remains common in many parts of the country.

Health experts stress that this injection must only be given under medical supervision because incorrect dosing or a rapid infusion rate can affect heart rhythm and blood pressure. Global health guidelines still recognize chloroquine as effective against vivax, ovale and malariae malaria in regions where resistance has not developed.

Specialists also caution that chloroquine resistant falciparum malaria is now widespread across parts of Asia, so doctors typically confirm the parasite species before starting this injection. Regular monitoring of vital signs during treatment helps catch rare but serious reactions early.

Drug Class

• Antimalarial (4-aminoquinoline)

Chloroquine Phosphate Injection 200mg/5ml formula

• Chloroquine Phosphate

Available forms

• Injection

How to use Chloroquine Phosphate Injection 200mg/5ml?

• Administered only by a doctor or trained healthcare worker in a hospital or clinic setting.
• Given as a slow intramuscular or slow intravenous infusion, never as a rapid injection.
• Dose and frequency are calculated based on the patient's body weight and the severity of malaria.
• Vital signs and heart rhythm are monitored during and after administration.
• Not intended for self injection or home use under any circumstance.

Drug Interactions

• Antacids: Can reduce chloroquine absorption if not properly spaced apart.
• Other QT Prolonging Drugs: Combining with certain antibiotics or antiarrhythmics raises heart rhythm risk.
• Mefloquine: Increases the risk of seizures when combined.
• Cimetidine: Can slow chloroquine breakdown and raise its levels in the body.
• Ampicillin: Chloroquine may reduce absorption of ampicillin when taken together.

Risks and warnings

• Retinal Toxicity: Long term or high dose use can damage the retina and affect eyesight permanently.
• Cardiac QT Prolongation: Can disturb heart rhythm, especially when combined with other QT prolonging medicines.
• Rapid Infusion Risk: A fast intravenous injection can cause dangerously low blood pressure and cardiac arrest.
• Liver Or Kidney Disease: Requires dose adjustment and close monitoring in patients with organ impairment.
• G6PD Deficiency: May trigger red blood cell breakdown in susceptible patients.
• Pregnancy: Should be used in pregnancy only when the benefit of treating malaria outweighs the potential risk.

Chloroquine Phosphate Injection 200mg/5ml Side Effects

• Nausea and vomiting
• Headache and dizziness
• Low blood pressure around the injection time
• Blurred vision
• Itching and skin rash
• Irregular heartbeat in rare cases
• Muscle weakness with prolonged use

Storage Conditions

• Store below 25°C, away from direct sunlight and heat.
• Keep the ampoule in its original box to protect it from light.
• Do not freeze.
• Use immediately after opening and discard any unused portion.
• Keep out of reach of children.