Crestat Tablet 20mg

About Crestat Tablet 20mg

Crestat Tablet 20mg Uses

• Lowers high LDL (bad) cholesterol and total cholesterol levels
• Reduces triglycerides and raises HDL (good) cholesterol
• Prevents heart attacks, stroke, and other cardiovascular events in high-risk patients
• Manages familial hypercholesterolemia, including in children with a strong family history
• Slows the progression of atherosclerosis in patients with existing heart disease

Crestat Tablet 20mg Benefits

• Achieves a greater LDL reduction than most other statins at an equivalent dose
• Once-daily dosing supports long term adherence
• Supports secondary prevention after a prior heart attack or stroke
• Can be combined with lifestyle changes for a stronger overall cholesterol reduction

What Experts Say

Cardiologists in Pakistan increasingly prescribe rosuvastatin over other statins because it achieves a greater LDL cholesterol reduction at lower milligram doses, an important factor given how frequently South Asian patients present with premature coronary artery disease. The 20mg strength is generally reserved for patients whose cholesterol remains uncontrolled on lower doses, or who carry a very high baseline cardiovascular risk from diabetes, prior heart attack, or strong family history.

Physicians typically order a baseline lipid panel and liver function test before starting this dose, then repeat both around 4 to 12 weeks later to confirm the response. Doctors also caution patients to report unexplained muscle pain or weakness promptly, since statin-related muscle injury becomes more likely at higher doses.

Because rosuvastatin is cleared mainly through the liver, doctors avoid it in active liver disease and use caution with other liver-affecting medicines. Most patients tolerate long-term therapy well once the maintenance dose is set.

Drug Class

• HMG-CoA reductase inhibitor (statin)

Crestat Tablet 20mg formula

• Rosuvastatin Calcium 20mg

Available forms

• Tablet

How to use Crestat Tablet 20mg?

• Take one tablet once daily, with or without food
• Swallow the tablet whole with a glass of water; do not crush or chew it
• Take it at the same time each day, preferably in the evening for the best cholesterol-lowering effect
• Continue taking it even if you feel well, since cholesterol control needs consistent daily use
• Do not stop the medicine without consulting your doctor, even if lipid levels normalize

Drug Interactions

• Cyclosporine: Significantly raises rosuvastatin blood levels.
• Warfarin: Requires closer INR monitoring when combined.
• Gemfibrozil And Other Fibrates: Increases the risk of muscle-related side effects.
• Antacids: Aluminium or magnesium containing antacids can lower drug absorption if taken together.
• Protease Inhibitors: Used in HIV treatment, can raise rosuvastatin levels.

Risks and warnings

• Pregnancy And Breastfeeding: Avoid use during pregnancy and breastfeeding, as statins can harm the developing baby.
• Kidney Disease: Use with caution in patients with kidney disease, since the 20mg dose needs adjustment for reduced kidney function.
• Liver Disease: Avoid in active liver disease or unexplained persistent rises in liver enzymes.
• Muscle Symptoms: Report any unexplained muscle pain, tenderness, or weakness immediately, especially with fever or dark urine.
• Asian Ancestry: Use cautiously in patients of Asian ancestry, who may need lower starting doses due to higher drug exposure.
• Children: Not recommended for children under 8 years of age.

Crestat Tablet 20mg Side Effects

• Headache
• Muscle pain or weakness (myalgia)
• Nausea or stomach upset
• Dizziness
• Weakness and fatigue
• Increased blood sugar levels
• Rare but serious muscle breakdown (rhabdomyolysis)
• Liver enzyme abnormalities

Storage Conditions

• Store below 30°C in a cool, dry place
• Keep the tablets in their original blister pack until ready to use
• Protect from direct sunlight and moisture
• Keep out of reach of children