About Daplyza - M tablet 5mg / 1000mg
Daplyza-M tablet 5mg/1000mg is a combination diabetes tablet for adults needing stronger blood sugar control.
Daplyza-M Tablet Uses
- Type 2 diabetes mellitus in adults who need more than one medicine for blood sugar control
- Add on therapy for patients not adequately controlled on metformin alone
- Combination treatment to reduce both fasting and after meal blood sugar
- Long term glycemic management alongside diet and exercise
- Blood sugar control in patients who may also benefit from modest weight reduction
Daplyza-M Tablet Benefits
- Targets blood sugar through two different mechanisms in one tablet
- May support modest weight loss compared with some other diabetes medicines
- Extended release metformin component reduces stomach related side effects
- Some added heart and kidney protective benefit has been shown with dapagliflozin
- Once daily dosing improves convenience
What Experts Say
Daplyza-M pairs dapagliflozin, an SGLT2 inhibitor, with metformin, a biguanide. Dapagliflozin works in the kidneys by blocking glucose reabsorption so extra sugar is passed out in urine, while metformin reduces glucose production in the liver and improves the body's response to insulin.
This combination is increasingly prescribed by Pakistani endocrinologists because dapagliflozin has shown added cardiovascular and kidney protective effects in clinical studies, which matters given how often diabetes and heart disease occur together in local patients. The extended release metformin component is generally gentler on the stomach than standard metformin.
Doctors typically check kidney function before starting this combination and periodically afterward, since dapagliflozin is less effective and generally avoided when kidney function is significantly reduced. Patients are advised to stay well hydrated because SGLT2 inhibitors increase urination.
Drug Class
- SGLT2 inhibitor (dapagliflozin)
- Biguanide (metformin)
Daplyza-M Tablet Uses in Urdu
- ٹائپ 2 ذیابیطس میں خون میں شوگر کی سطح کو کنٹرول کرنے کے لیے استعمال ہوتی ہے
- جب اکیلی میٹفارمن سے شوگر قابو میں نہ آئے تو یہ مجموعہ دوا تجویز کی جاتی ہے
- وزن میں معمولی کمی لانے میں بھی مددگار ثابت ہو سکتی ہے
- روزانہ ایک بار کھانے کے ساتھ لی جاتی ہے
Daplyza - M tablet 5mg / 1000mg formula
- Dapagliflozin
- Metformin Hydrochloride
How to use Daplyza - M tablet 5mg / 1000mg?
- Daplyza-M tablet is usually taken once daily in the morning with food
- The tablet should be swallowed whole and not crushed or chewed, since it is an extended release formulation
- Adequate fluid intake is recommended while taking this medicine
- Blood sugar levels should be monitored regularly as advised by the doctor
- The dose is adjusted gradually by the treating physician based on response and kidney function
Drug Interactions
- Insulin and sulfonylureas: Combining with these raises the risk of hypoglycemia and may require a dose adjustment
- Diuretics: Water pills combined with this medicine can increase the risk of dehydration and low blood pressure
- Iodinated contrast dye: Metformin is usually paused around the time of imaging scans that use contrast dye due to kidney related risks
- Alcohol: Heavy alcohol use raises the risk of lactic acidosis with metformin
- Corticosteroids: Steroid medicines can raise blood sugar and reduce the effectiveness of this combination
Risks and warnings
- Kidney function: Dapagliflozin is less effective and generally avoided when kidney function is significantly reduced, so kidney tests are checked periodically
- Genital and urinary infections: This combination increases the risk of yeast infections and urinary tract infections due to increased sugar in the urine
- Dehydration and low blood pressure: Increased urination can cause dehydration, particularly in elderly patients or those on diuretics
- Lactic acidosis: A rare but serious risk with metformin, more likely in patients with significant kidney or liver impairment
- Diabetic ketoacidosis: SGLT2 inhibitors carry a small risk of ketoacidosis even with only mildly raised blood sugar, so unusual nausea or breathlessness should be reported promptly
Daplyza-M Tablet Side Effects
Most patients tolerate this medicine reasonably well.
- Genital yeast infections
- Urinary tract infections
- Increased urination
- Nausea or mild stomach upset
- Diarrhea
- Low blood sugar when combined with other diabetes medicines
Rare but serious reactions need prompt medical attention.
- Signs of diabetic ketoacidosis such as nausea, vomiting and unusual tiredness
- Signs of a severe urinary infection such as fever with back pain
Storage Conditions
- Store at room temperature away from moisture and direct heat
- Keep the tablet in its original strip until it is time to take it
- Avoid storing in the bathroom where humidity is high
- Keep out of reach of children.
