Detriflow Tablet 2mg

About Detriflow Tablet 2mg

Detriflow Tablet 2mg Uses

• Overactive bladder (OAB) syndrome
• Urinary urgency and frequent urination
• Urge urinary incontinence
• Unstable bladder with involuntary detrusor contractions

Detriflow Tablet 2mg Benefits

• Reduces episodes of sudden urinary urgency
• Increases the interval between bathroom visits
• Lowers the number of urge incontinence episodes
• Improves overall bladder control and daily comfort

What Experts Say

Tolterodine works as a competitive antagonist at muscarinic receptors, mainly the M2 and M3 subtypes found in bladder detrusor muscle. By blocking acetylcholine at these receptor sites, it reduces involuntary detrusor contractions that occur during the bladder filling phase. This action increases functional bladder capacity and delays the urge to void.

Clinical data on tolterodine show bladder selectivity comparable to oxybutynin but with a more favorable tolerability profile, particularly regarding dry mouth severity. Improvement in urgency and incontinence frequency is often measurable within one to two weeks of regular dosing. Full benefit on daytime frequency and nocturia usually needs about four weeks of consistent treatment.

Because tolterodine circulates systemically and carries anticholinergic activity, clinicians weigh its use carefully in older adults and in patients with narrow-angle glaucoma, myasthenia gravis, or hepatic and renal impairment. Drug clearance can slow in these groups, raising the risk of dry mouth, constipation, and cognitive side effects, so dose review is often advised.

Drug Class

• Antimuscarinic (Anticholinergic)
• Urinary Antispasmodic

Detriflow Tablet 2mg formula

• Tolterodine

Available forms

• Tablet

How to use Detriflow Tablet 2mg?

• Take one tablet daily at the same time each day, with or without food.
• Swallow the tablet whole with a glass of water without crushing or chewing it.
• Continue treatment for the duration your doctor prescribes, usually at least four weeks before assessing full benefit.
• Do not double the dose if a tablet is missed; take the next dose at the regular scheduled time.

Drug Interactions

• CYP3A4 Inhibitors (Ketoconazole, Itraconazole, Clarithromycin): These raise tolterodine blood levels and increase the risk of side effects, so dose adjustment may be needed.
• Other Anticholinergic Drugs: Combining with antihistamines or other anticholinergics increases dry mouth, constipation, and blurred vision.
• CYP2D6 Inhibitors (Fluoxetine, Paroxetine): These can slow tolterodine metabolism and raise plasma concentration.
• Alcohol: May increase drowsiness and dizziness when taken along with this medicine.

Risks and warnings

• Urinary Retention: Avoid use in significant urinary retention or uncontrolled narrow-angle glaucoma since the drug can worsen bladder and gastric emptying.
• Glaucoma: Use with caution in narrow-angle glaucoma since anticholinergic action can raise intraocular pressure.
• Liver Or Kidney Impairment: Dose reduction may be needed since reduced clearance can raise drug exposure and side effects.
• Elderly Patients: Monitor closely for confusion, dizziness, or falls linked to anticholinergic burden.
• Pregnancy And Breastfeeding: Use only if clearly needed and prescribed by a doctor since safety data in these groups is limited.
• Driving Or Operating Machinery: Blurred vision or dizziness may occur, so caution is advised until individual response is known.

Detriflow Tablet 2mg Side Effects

• Dry mouth
• Constipation
• Headache
• Dizziness
• Blurred vision
• Dry eyes
• Abdominal discomfort or indigestion
• Fatigue

Storage Conditions

• Store below 30°C in a cool, dry place away from direct sunlight.
• Keep the tablets in their original blister pack until the time of use.
• Keep out of reach of children.
• Discard any tablets past the printed expiry date.