Diagesic Extra Tablet 37.5 / 325mg

About Diagesic Extra Tablet 37.5 / 325mg

Diagesic Extra Tablet 37.5 / 325mg Uses

• Moderate to severe acute pain
• Post operative pain after surgery
• Musculoskeletal pain from injuries or sprains
• Back pain and joint pain
• Chronic pain conditions such as osteoarthritis
• Pain that does not respond well to paracetamol or NSAIDs alone

Diagesic Extra Tablet 37.5 / 325mg Benefits

• Provides stronger pain relief than paracetamol alone through a dual mechanism
• Allows lower opioid dosing compared to tramadol used by itself
• Works faster for acute pain flare ups than single ingredient painkillers
• Helps patients manage pain after minor surgical procedures
• Supports better daily function when pain limits movement or sleep

What Experts Say

Tramadol works on the central nervous system through two combined mechanisms. It binds to opioid receptors to reduce pain signals, and it also blocks the reuptake of serotonin and norepinephrine, which adds a second layer of pain relief not typically seen with standard opioids alone.

Paracetamol acts through a different pathway, reducing prostaglandin production in the brain and spinal cord to lower pain perception and fever. Combining the two ingredients allows lower doses of each, which helps control moderate to severe pain while limiting opioid related side effects like sedation.

Clinical evidence supports this fixed dose combination for short term management of acute pain that does not respond well to paracetamol or NSAIDs alone. Long term use requires close medical supervision because tolerance, physical dependence, and paracetamol related liver strain can develop with prolonged or excessive intake.

Drug Class

• Opioid analgesic combination
• Centrally acting analgesic
• Non opioid antipyretic and analgesic (paracetamol component)

Diagesic Extra Tablet 37.5 / 325mg formula

• Tramadol Hydrochloride 37.5mg + Paracetamol 325mg

Available forms

• Tablet

How to use Diagesic Extra Tablet 37.5 / 325mg?

• Take exactly as prescribed by your doctor, usually one tablet every four to six hours as needed for pain
• Do not exceed the maximum dose set by your doctor in a 24 hour period
• Swallow the tablet whole with a glass of water
• Can be taken with or without food, though food may reduce stomach upset
• Do not use for longer than your doctor has advised
• Do not stop suddenly after regular use without medical guidance

Drug Interactions

• Other Opioids or Sedatives: Combining with benzodiazepines, sleeping pills, or other opioids increases the risk of severe drowsiness and slowed breathing.
• MAO Inhibitors: Use within 14 days of MAOIs can cause dangerous reactions and is generally avoided.
• SSRIs and SNRIs: Taking tramadol with these antidepressants raises the risk of serotonin syndrome.
• Alcohol: Increases sedation and raises the risk of liver damage from the paracetamol component.
• Carbamazepine: Can reduce the pain relieving effect of tramadol by speeding up its breakdown.
• Warfarin: Tramadol may increase the effect of blood thinners, raising bleeding risk.
• Other Paracetamol Containing Products: Using additional paracetamol products can lead to accidental overdose and liver injury.

Risks and warnings

• Opioid Dependence: Tramadol carries a risk of tolerance, physical dependence, and misuse, especially with prolonged or high dose use.
• Respiratory Depression: High doses or use with other sedating drugs can slow breathing to a dangerous level.
• Liver Damage: The paracetamol component can cause serious liver injury if the maximum daily dose is exceeded or combined with alcohol.
• Seizure Risk: Tramadol can lower the seizure threshold, particularly in people with epilepsy or on certain other medicines.
• Pregnancy and Breastfeeding: Use only if clearly advised by a doctor, since tramadol crosses the placenta and passes into breast milk.
• Elderly and Kidney or Liver Impairment: Dose adjustment is usually needed because clearance of both ingredients is slower.
• Driving and Operating Machinery: This medicine can cause drowsiness and dizziness that impair alertness.

Diagesic Extra Tablet 37.5 / 325mg Side Effects

• Nausea and vomiting
• Dizziness and drowsiness
• Constipation
• Dry mouth
• Headache
• Sweating
• Fatigue
• Insomnia
• Loss of appetite
• Skin rash or itching
• Confusion in older adults
• Difficulty breathing in overdose or with other sedatives

Storage Conditions

• Store below 30 degrees Celsius in a cool, dry place
• Keep the tablets in their original blister pack away from direct sunlight
• Keep out of reach of children
• Do not store in the bathroom or near moisture
• Dispose of expired or unused tablets safely and do not share with others