Diajard-M Tablets 500mg / 12.5mg

About Diajard-M Tablets 500mg / 12.5mg

Diajard-M Tablets 500mg / 12.5mg Uses

• Type 2 diabetes mellitus management
• Blood sugar control when diet and exercise alone are not enough
• Used alongside insulin or other antidiabetic drugs when advised by a doctor

Diajard-M Tablets 500mg / 12.5mg Benefits

• Combines two complementary mechanisms for stronger glucose control
• Empagliflozin lowers blood sugar by removing excess glucose through urine
• Metformin reduces liver glucose production and improves insulin sensitivity
• May support modest weight reduction compared with some other diabetes tablets
• Single tablet dosing improves adherence over taking two separate pills

What Experts Say

Empagliflozin and Metformin target blood sugar through two different pathways, which is why endocrinologists often combine them in a single tablet. Empagliflozin blocks the SGLT2 protein in the kidneys, preventing glucose reabsorption so extra sugar leaves the body through urine. Metformin lowers glucose output from the liver and helps muscle tissue use insulin more effectively.

Because Empagliflozin depends on kidney function to work, doctors check renal parameters before starting this combination and periodically afterward. Patients with reduced kidney function may need a lower dose or a different antidiabetic regimen altogether. Adequate hydration is also emphasized, since SGLT2 inhibitors increase urination and can raise the risk of dehydration in hot weather.

Type 2 diabetes affects a large proportion of adults in Pakistan, and many patients eventually need more than one oral agent to reach their target HbA1c. This fixed-dose combination is prescribed when metformin alone no longer provides adequate control, offering a practical two-in-one option with added cardiovascular and weight benefits seen in SGLT2 inhibitor trials.

Drug Class

• SGLT2 Inhibitor
• Biguanide
• Oral Antidiabetic Combination

Diajard-M Tablets 500mg / 12.5mg formula

• Empagliflozin + Metformin Hydrochloride

Available forms

• Tablet

How to use Diajard-M Tablets 500mg / 12.5mg?

• Take one tablet by mouth once daily with breakfast, unless your doctor advises otherwise
• Swallow the tablet whole with a glass of water
• Do not crush or chew the tablet
• Take at the same time each day for consistent blood sugar control
• Follow the dose and diet plan given by your doctor

Drug Interactions

• Insulin/Sulfonylureas: Combined use raises the risk of hypoglycemia and may need dose adjustment
• Diuretics: Can add to fluid loss and increase dehydration risk
• Contrast Dye: Metformin is usually paused around procedures using iodinated contrast due to kidney injury risk
• Alcohol: Excess alcohol raises the risk of lactic acidosis and low blood sugar
• Corticosteroids: Can raise blood sugar and reduce the medicine's effectiveness

Risks and warnings

• Kidney Function: Not recommended for patients with significantly reduced kidney function, since Empagliflozin needs adequate renal clearance to work safely
• Dehydration: Increased urination can lower blood volume, so maintain fluid intake, especially in hot weather or during illness
• Lactic Acidosis: Rare but serious risk with Metformin, more likely in patients with kidney or liver impairment
• Ketoacidosis: SGLT2 inhibitors carry a rare risk of diabetic ketoacidosis even with near normal blood sugar levels
• Genital Infections: Higher urinary glucose levels can increase the risk of yeast and urinary tract infections
• Surgery: Usually stopped before planned surgery or contrast imaging procedures, per your doctor's advice

Diajard-M Tablets 500mg / 12.5mg Side Effects

• Urinary tract infections
• Genital yeast infections
• Increased urination
• Nausea or upset stomach
• Diarrhea
• Low blood sugar when combined with insulin or sulfonylureas
• Dizziness from fluid loss
• Metallic taste
• Vitamin B12 deficiency with long term use

Storage Conditions

• Store below 30°C in a cool, dry place
• Keep the tablet in its original blister pack until use
• Protect from moisture and direct sunlight
• Keep out of reach of children