Diclofenac sodium injection 75mg / 3ml

About Diclofenac sodium injection 75mg / 3ml

Diclofenac Sodium Injection 75mg/3ml Uses

• Post operative pain after surgery
• Post traumatic pain following injuries, sprains, and fractures
• Acute renal colic caused by kidney stones
• Acute musculoskeletal pain including low back pain and sciatica
• Acute flare ups of osteoarthritis and rheumatoid arthritis
• Acute gout attacks
• Moderate to severe pain when oral medicines are not practical

Diclofenac Sodium Injection 75mg/3ml Benefits

• Provides fast pain relief since the injectable route bypasses the gut and acts quicker than tablets
• Reduces inflammation and swelling at the site of injury or surgery
• Useful for patients who cannot take oral medicine due to vomiting or difficulty swallowing
• Helps control severe acute pain in an emergency or hospital setting

What Experts Say

Doctors across Pakistan often choose an injectable NSAID like diclofenac sodium when a patient needs fast control of severe acute pain, such as right after surgery or a traumatic injury, since oral tablets take longer to act and may not be tolerated if the patient feels nauseated. The intramuscular route lets the drug reach therapeutic blood levels quickly, which is why it is common in emergency rooms and post operative wards.

Physicians generally keep diclofenac sodium injection to short term use, usually one to two days, and switch the patient to oral NSAIDs or safer alternatives once acute pain settles. This approach balances quick pain relief against the known gastrointestinal, kidney, and cardiovascular risks tied to repeated NSAID dosing, a real concern given how often NSAIDs are used for musculoskeletal complaints in Pakistan.

Drug Class

• Nonsteroidal anti inflammatory drug (NSAID)
• Phenylacetic acid derivative

Diclofenac sodium injection 75mg / 3ml formula

• Diclofenac Sodium

Available forms

• Injection

How to use Diclofenac sodium injection 75mg / 3ml?

• Given only by a doctor or trained healthcare professional as a deep intramuscular injection into the gluteal muscle
• Typical adult dose is 75mg once or twice a day, not exceeding 150mg in 24 hours
• Usually given for one to two days only, then switched to an oral or rectal NSAID if pain continues
• Not meant for self administration at home
• Injected slowly to reduce discomfort and the risk of injection site reaction
• Should not be mixed in the same syringe with other injectable medicines

Drug Interactions

• Other NSAIDs or aspirin: Combined use raises the risk of stomach ulcers and gastrointestinal bleeding
• Blood thinners like warfarin: Increases the risk of serious bleeding
• ACE inhibitors and ARBs: Diclofenac can reduce their blood pressure lowering effect and worsen kidney function together
• Diuretics: Reduces their effectiveness and raises the risk of kidney impairment when combined
• Corticosteroids: Combined use further increases the risk of stomach ulcers and bleeding
• Lithium and methotrexate: Diclofenac can raise blood levels of these drugs and increase toxicity risk
• Cyclosporine: Combined use can worsen kidney toxicity

Risks and warnings

• Gastrointestinal bleeding: Can cause stomach ulcers, bleeding, or perforation, especially with a history of ulcers or in elderly patients
• Cardiovascular risk: Prolonged or high dose use can raise the risk of heart attack, stroke, and high blood pressure
• Kidney impairment: Can reduce kidney blood flow and worsen kidney function, particularly in dehydrated patients or those with existing kidney disease
• Injection site reactions: May cause pain, swelling, or in rare cases an abscess or tissue damage at the injection site
• Pregnancy caution: Should be avoided in the last trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus
• Liver effects: Can raise liver enzymes and rarely cause serious liver injury with prolonged use
• Short term use only: Intended for acute pain under medical supervision, not for long term or chronic pain management
• Bleeding risk: Increases bleeding tendency, so caution is needed before and after surgical procedures

Diclofenac Sodium Injection 75mg/3ml Side Effects

• Pain, redness, or swelling at the injection site
• Nausea or vomiting
• Stomach pain or indigestion
• Headache and dizziness
• Diarrhea or constipation
• Fluid retention or mild swelling of the feet
• Raised blood pressure
• Gastrointestinal bleeding or ulcers
• Allergic skin reactions such as rash or itching
• Kidney function changes
• Rare serious allergic reaction with breathing difficulty or facial swelling

Storage Conditions

• Store at room temperature, below 25 degrees Celsius
• Protect ampoules from light by keeping them in the original carton
• Do not freeze
• Do not use if the solution appears discolored, cloudy, or contains visible particles
• Each ampoule is for single use only, discard any unused portion after opening
• Keep out of reach of children