Difen Injection 75mg / 3ml

About Difen Injection 75mg / 3ml

Difen Injection 75mg / 3ml Uses

• Acute moderate to severe pain
• Postoperative pain management
• Acute renal colic pain
• Acute gout attacks
• Severe musculoskeletal and joint pain flare ups

Difen Injection 75mg / 3ml Benefits

• Provides fast pain relief when oral medicines are not practical
• Useful for severe pain in hospital and emergency settings
• Reduces inflammation quickly at the site of injury
• Helpful for patients unable to swallow tablets due to vomiting or surgery

What Experts Say

Diclofenac sodium works by inhibiting cyclooxygenase enzymes, reducing the production of prostaglandins that drive pain, swelling and fever. Given by intramuscular injection, it bypasses the digestive tract, allowing faster absorption into the bloodstream compared to oral tablets, which is valuable when rapid pain control is needed.

Clinical response after an intramuscular dose is typically noticeable within fifteen to thirty minutes, making injectable diclofenac a common choice for acute severe pain such as renal colic or postoperative discomfort where oral medicines may act too slowly or cannot be tolerated due to vomiting.

Because injectable NSAIDs carry a stronger cardiovascular and gastrointestinal risk profile than lower dose oral forms, clinicians limit use to one or two days before transitioning to oral or rectal diclofenac, and they screen for heart disease, kidney impairment and bleeding risk before administering the injection.

Drug Class

• Non Steroidal Anti Inflammatory Drug (NSAID)
• Analgesic
• Antipyretic

Difen Injection 75mg / 3ml formula

• Diclofenac Sodium

Available forms

• Injection

How to use Difen Injection 75mg / 3ml?

• Difen injection is given by a trained healthcare professional through deep intramuscular injection
• It is usually given into the gluteal muscle, never into a vein
• Treatment is generally limited to one or two days before switching to oral or rectal diclofenac
• Do not self administer this injection at home without medical supervision
• Inform your doctor about any stomach, heart or kidney problems before the injection is given

Drug Interactions

• Blood Thinners: Combining with warfarin or heparin raises the risk of serious bleeding
• Other NSAIDs: Using with ibuprofen or aspirin increases the risk of stomach ulcers
• ACE Inhibitors: Diclofenac can reduce the blood pressure lowering effect of drugs like perindopril and stress the kidneys
• Diuretics: Combined use can reduce the effectiveness of water pills and affect kidney function
• Lithium: Diclofenac can raise lithium levels in the blood, increasing toxicity risk

Risks and warnings

• Heart Risk: Injectable diclofenac can increase the risk of heart attack or stroke, particularly with prolonged use or high doses
• Stomach Bleeding: NSAIDs like diclofenac can cause stomach ulcers or bleeding, especially in older adults
• Kidney Function: Difen should be used cautiously in patients with existing kidney disease or dehydration
• Injection Site Reaction: Pain, swelling or rarely tissue damage can occur at the injection site if not given correctly
• Pregnancy: Avoid in the third trimester as it can affect the baby and prolong labor
• Allergic Reaction: Patients with known NSAID or aspirin allergy should not receive this injection

Difen Injection 75mg / 3ml Side Effects

• Pain or burning at the injection site
• Nausea
• Stomach discomfort
• Headache
• Dizziness
• Drowsiness
• Fluid retention with mild swelling
• Rise in blood pressure
• Rare but serious stomach bleeding
• Rare but serious allergic reaction with breathing difficulty or facial swelling

Storage Conditions

• Store below 25°C protected from light
• Keep ampoules in their original box until immediately before use
• Keep out of reach of children
• Do not use if the solution appears discolored or contains particles
• Discard any opened ampoule that is not used immediately