Entamizole suspension 250mg / 200mg

About Entamizole suspension 250mg / 200mg

Entamizole Suspension Uses

• Treatment of intestinal amoebiasis, also known as amoebic dysentery
• Clearing Entamoeba histolytica cysts from the intestine after active infection
• Treatment of amoebic diarrhea with blood or mucus in the stool
• Management of giardiasis, a common parasitic gut infection
• Treatment of mixed protozoal and anaerobic bacterial infections of the gut
• Reducing the chance of relapse after an acute amoebic dysentery episode

Entamizole Suspension Benefits

• Combines a tissue acting agent and a gut acting agent for more complete amoebiasis treatment
• Suspension form is easier for children and for adults who cannot swallow tablets
• Helps clear amoebic cysts, lowering the risk of the infection coming back
• Offers combination therapy in a single bottle instead of two separate medicines
• Widely available and affordable across pharmacies in Pakistan

What Experts Say

Doctors across Pakistan often prescribe combination antiamoebic suspensions because amoebic infections remain common due to contaminated water and food sources. Metronidazole acts against the invasive tissue form of the amoeba, while diloxanide furoate works within the intestine to clear the cyst form that causes relapse.

Physicians recommend completing the entire course even after symptoms improve, since stopping early is a common reason for treatment failure and continued cyst shedding. In Pakistan, waterborne parasitic infections tend to rise during the hot and humid months, making a complete course important for full recovery.

The suspension form is generally preferred for children and for patients who find tablets difficult to swallow. Physicians usually pair this treatment with advice on safe drinking water and hygiene, since reinfection with amoebic parasites is common without these precautions.

Drug Class

• Antiprotozoal and antiamoebic combination, metronidazole is a nitroimidazole antibacterial and antiprotozoal, diloxanide furoate is a luminal amoebicide

Entamizole suspension 250mg / 200mg formula

• Diloxanide Furoate + Metronidazole

Available forms

• Suspension
• Tablet
• DS Tablet

How to use Entamizole suspension 250mg / 200mg?

• Shake the bottle well before every use to mix the suspension evenly
• Use the measuring cup or spoon provided to measure the exact dose
• Give the dose by mouth, with or after food, to reduce stomach upset
• Follow the exact dose and duration prescribed by the doctor based on age and weight
• Complete the full course even if symptoms improve within a few days
• Do not mix the suspension with alcohol based liquids
• Keep dosing at evenly spaced times each day for consistent effect

Drug Interactions

• Alcohol: Causes a severe reaction with flushing, nausea, and a rapid heartbeat when combined with metronidazole, so it must be avoided.
• Warfarin: Metronidazole can increase the blood thinning effect, raising the risk of bleeding, so doses may need monitoring.
• Lithium: Can raise lithium levels in the blood, so kidney function and lithium levels should be checked if used together.
• Phenytoin and phenobarbital: These seizure medicines can change how quickly metronidazole is cleared from the body.
• Disulfiram: Taking disulfiram close to metronidazole can trigger confusion or psychotic reactions, so they should not be combined.
• Cimetidine: Can slow down the breakdown of metronidazole, increasing its levels in the blood.

Risks and warnings

• Pregnancy: Metronidazole is generally avoided in the first trimester and used only if the doctor considers it clearly necessary.
• Breastfeeding: Metronidazole passes into breast milk, so doctors may advise a temporary pause in breastfeeding during treatment.
• Liver disease: Patients with significant liver impairment may need a lower dose since both ingredients are processed by the liver.
• Blood disorders: Use with caution in patients with a history of low blood cell counts, since metronidazole can affect blood counts with prolonged use.
• Neurological conditions: Patients with epilepsy or nerve disorders should be monitored, as metronidazole can rarely affect the nervous system.
• Children: Dosing must be calculated strictly by body weight and age, so a doctor should confirm the exact amount before starting.
• Alcohol use: Alcohol must be avoided during and for at least two days after treatment due to a severe reaction with metronidazole.

Entamizole Suspension Side Effects

• Nausea and vomiting
• Metallic or bitter taste in the mouth
• Loss of appetite
• Abdominal discomfort or cramping
• Diarrhea or loose stools
• Headache and dizziness
• Dark or discolored urine
• Skin rash or itching
• Dry mouth or unusual taste changes
• Rare numbness or tingling in the hands or feet with prolonged use
• Rare seizures with very high or prolonged dosing

Storage Conditions

• Store the bottle at room temperature, below 30°C, away from direct heat and sunlight
• Keep the suspension away from Pakistan's hot summer temperatures, in a cool, dry cabinet
• Shake well before each use since the ingredients can settle over time
• Keep the bottle cap tightly closed between uses
• Keep out of reach and sight of children
• Do not use the suspension after the expiry date printed on the bottle
• Discard any leftover suspension once the prescribed course is finished