Glandin E-2 Vaginal Gel 2mg

About Glandin E-2 Vaginal Gel 2mg

Glandin E-2 Vaginal Gel 2mg Uses

• Cervical ripening before induction of labor in a hospital setting
• Induction of labor in pregnancies at or near term with a medical indication
• Management of an unfavorable Bishop score before planned induction

Glandin E-2 Vaginal Gel 2mg Benefits

• Softens and prepares the cervix for a smoother, faster labor process
• Reduces the need for higher doses of other induction agents like oxytocin
• Delivered directly into the vagina for targeted, localized action

What Experts Say

Dinoprostone is a synthetic form of prostaglandin E2, a hormone-like compound the body naturally produces to help the cervix soften, thin out and open before labor begins. When placed inside the vagina, it acts directly on the cervical tissue to trigger this ripening process ahead of induction.

Obstetricians choose this gel when the cervix is not yet ready for labor to start on its own, a readiness level often described using the Bishop score. A low score means induction with oxytocin alone is less likely to succeed quickly, so cervical ripening with dinoprostone usually comes first.

Because dinoprostone can also trigger strong or repeated uterine contractions, it is given only inside a hospital or maternity unit where the mother and baby can be monitored continuously on a fetal heart rate machine. This setup lets the care team catch and manage any excessive contraction pattern early, before it becomes risky.

Drug Class

• Prostaglandin E2 analogue (uterotonic / cervical ripening agent)

Glandin E-2 Vaginal Gel 2mg formula

• Dinoprostone

Available forms

• Vaginal Gel

How to use Glandin E-2 Vaginal Gel 2mg?

• Administered only by a qualified doctor or nurse inside a hospital or maternity unit
• One gel applicator (2mg) is inserted high into the posterior vaginal fornix
• The mother stays lying down for at least 30 minutes after insertion
• Uterine activity and fetal heart rate are monitored continuously after the dose
• A repeat dose is given only if the treating doctor confirms it is needed

Drug Interactions

• Oxytocin: Combining or closely timing with oxytocin increases the risk of uterine hyperstimulation, so oxytocin is usually delayed for several hours after gel removal.
• Other Prostaglandins: Should not be used together with other prostaglandin-based induction agents, as effects can add up dangerously.
• Nonsteroidal Anti Inflammatory Drugs: NSAIDs can blunt the cervical ripening effect of dinoprostone by blocking prostaglandin activity.

Risks and warnings

• Uterine Hyperstimulation: Can cause excessive or prolonged contractions that reduce oxygen supply to the baby, so continuous monitoring is required.
• Fetal Distress: Requires immediate removal of the gel and emergency care if abnormal fetal heart patterns appear.
• Not For Home Use: This gel must never be self-administered outside a hospital or clinic setting.
• Prior Cesarean Section: Carries a higher risk of uterine rupture and is generally avoided.
• Asthma And Glaucoma: Used with caution, as prostaglandins can worsen bronchospasm and raise intraocular pressure.

Glandin E-2 Vaginal Gel 2mg Side Effects

• Uterine hyperstimulation or unusually strong contractions
• Nausea and vomiting
• Diarrhea
• Fever or chills
• Headache
• Vaginal warmth or irritation at the site of insertion
• Abnormal fetal heart rate changes

Storage Conditions

• Store in a refrigerator between 2°C and 8°C, away from freezing
• Keep the gel in its original sealed applicator until the doctor is ready to use it
• Protect from light and do not remove from the fridge until immediately before use
• Keep out of reach of children and unauthorized staff