Glucophage Tablet 500mg

About Glucophage Tablet 500mg

Glucophage Tablet Uses

• Treating type 2 diabetes mellitus
• Controlling blood sugar levels in adults
• Preventing or delaying onset of type 2 diabetes in high-risk patients
• Managing polycystic ovary syndrome and fertility issues
• Reducing cardiovascular complications in diabetic patients

Glucophage Tablet Benefits

• Effectively lowers blood sugar without causing low blood sugar
• Does not stimulate insulin production
• Helps with weight management in diabetic patients
• Reduces risk of heart disease and stroke
• Safe and well-tolerated long-term treatment

What Experts Say

Metformin is a biguanide that reduces hepatic glucose production and increases glucose uptake and utilization in peripheral tissues. By activating AMP-activated protein kinase, it enhances insulin sensitivity without stimulating insulin secretion. This mechanism prevents hypoglycemia and weight gain associated with other antidiabetic agents.

Endocrinologists recommend Glucophage as first-line therapy for type 2 diabetes. It is particularly effective in overweight patients and those with insulin resistance. The medication reduces HbA1c by 1 to 2 percent and substantially lowers cardiovascular event risk.

Take Glucophage with meals to minimize gastrointestinal upset. Start with low doses and titrate gradually. Monitor renal function regularly as metformin requires dose adjustment in kidney disease.

Drug Class

• Biguanide Antidiabetic Agent

Packaging and Quantity

• Tablet 500 mg, 50 tablets per box (5 strips of 10)
• Tablet 500 mg, 30 tablets per box (3 strips of 10)

When Not to Use Glucophage

• Allergy to metformin or any ingredient
• Severe kidney disease or renal impairment
• Acute illness, severe infection, or sepsis
• Lactic acidosis or history of lactic acidosis

Glucophage Tablet 500mg formula

• Metformin

Available forms

• Tablets

How to use Glucophage Tablet 500mg?

• Swallow it whole with a glass of water
• Take it half an hour before food intake
• Do not crush or chew the tablet.
• The recommended dosage of Glucophage tablet is 500mg twice a day. However, it may vary according to condition.

Contraindications

The use of Glucophage tablet is contraindicated in the following conditions:

• Diabetic ketoacidosis
• Liver or kidneys impairment
• Cardiac or respiratory failure

Drug Interactions

• Iodinated contrast agents: Hold metformin 48 hours before and after contrast procedures to prevent lactic acidosis.
• Alcohol: Excess alcohol increases lactic acidosis risk. Limit intake.
• Other diabetes medications: May increase hypoglycemia risk. Monitor blood sugar.

Risks and warnings

• Lactic acidosis: Rare but serious risk, especially in kidney disease. Monitor renal function.
• Kidney function: Requires regular monitoring. Do not use if eGFR less than 30.
• Vitamin B12 absorption: Long-term use may reduce B12 levels. Monitor if deficiency symptoms appear.
• Pregnancy: Generally safe. Continue during pregnancy under medical supervision.

Glucophage Tablet Side Effects

Most side effects are mild and often decrease with time:

• Nausea or vomiting
• Abdominal pain or cramping
• Diarrhea or constipation
• Loss of appetite
• Metallic taste in mouth

Serious side effects require immediate medical attention:

• Severe allergic reaction: Rash, swelling, difficulty breathing
• Lactic acidosis: Muscle pain, trouble breathing, severe nausea
• Severe hypoglycemia: Confusion, weakness, sweating
• Vitamin B12 deficiency signs: Numbness or tingling

Storage Conditions

• Store below 25 degrees Celsius in a cool, dry place
• Keep away from direct light and moisture
• Keep in original blister or container
• Do not store in bathroom or kitchen
• Keep out of reach of children
• Do not use after expiration date