About Isoniazid Tablet 100mg
Isoniazid Tablet 100mg contains isoniazid, an antitubercular drug used for TB treatment and prevention.
Isoniazid Tablet 100mg Uses
- Treats active tuberculosis as part of combination therapy with rifampicin, pyrazinamide and ethambutol, especially for weight based dosing
- Used in the continuation phase of TB treatment alongside rifampicin
- Prevents active tuberculosis in people with latent TB infection
- Suitable for lower weight adults and older children who need a smaller isoniazid dose
Isoniazid Tablet 100mg Benefits
- Allows precise, weight adjusted dosing for patients who do not need the full 300mg strength
- Effective bactericidal action against actively multiplying TB bacteria
- Convenient for combining multiple tablets to reach an exact prescribed dose
- Supports Pakistan's TB prevention and treatment programs at an affordable cost
What Experts Say
Doctors often reach for the 100mg isoniazid tablet when a patient's prescribed dose does not match the standard 300mg strength. Isoniazid dosing is calculated by body weight, so children and lower weight adults frequently need a smaller or combined dose that the 100mg tablet makes easier to achieve. This flexibility matters most during the intensive phase of TB treatment.
Physicians still watch for the same safety concerns at this lower strength, particularly liver function and nerve health. Vitamin B6, or pyridoxine, is commonly added to the regimen to prevent the tingling and numbness that isoniazid can cause in the hands and feet over time. Regular liver function checks are recommended for patients on longer courses.
Pakistan continues to report one of the highest tuberculosis case burdens globally, and completing the full prescribed course is the biggest factor in preventing drug resistant strains. Doctors across the country encourage patients to stick to directly observed therapy schedules and never adjust the dose on their own.
Drug Class
- Antitubercular agent
- Isonicotinic acid hydrazide derivative
Isoniazid Tablet 100mg Uses in Urdu
- فعال ٹی بی کے علاج میں دیگر ادویات کے ساتھ ملا کر استعمال ہوتی ہے
- ٹی بی سے بچاؤ کے لیے قریبی رابطے میں رہنے والے افراد کو دی جاتی ہے
- وزن کے حساب سے خوراک ایڈجسٹ کرنے کے لیے بچوں اور کم وزن بالغ افراد میں استعمال ہوتی ہے
- کمزور مدافعتی نظام رکھنے والے افراد میں ٹی بی سے حفاظت کے لیے استعمال ہوتی ہے
Isoniazid Tablet 100mg formula
How to use Isoniazid Tablet 100mg?
- Take Isoniazid Tablet 100mg exactly as prescribed, the number of tablets depends on your calculated dose
- Take on an empty stomach, at least one hour before or two hours after a meal
- Swallow the tablet whole with water, do not crush unless advised by your doctor
- Take alongside vitamin B6 (pyridoxine) if prescribed
- Complete the entire course of treatment without stopping early
- Follow your directly observed therapy schedule if enrolled in Pakistan's National TB Control Program
- Avoid alcohol throughout the treatment period
Drug Interactions
- Phenytoin: Isoniazid can raise phenytoin blood levels, increasing the risk of toxicity, so monitoring is needed
- Rifampin: Standard in TB regimens together, but the combination raises the overall risk of liver toxicity
- Alcohol: Increases the risk of liver damage and should be avoided during treatment
- Paracetamol: Frequent or high dose use alongside isoniazid may add to the risk of liver injury
- Antacids: Aluminum containing antacids can reduce absorption, so doses should be spaced a few hours apart
- Carbamazepine: Isoniazid may increase carbamazepine levels, raising the chance of side effects
Risks and warnings
- Liver Damage: Isoniazid can cause hepatotoxicity, ranging from mild enzyme elevation to serious hepatitis, with higher risk in adults over 35 or those with pre existing liver disease
- Peripheral Neuropathy: Long term use may cause numbness, tingling or burning sensations in the hands and feet, largely preventable with vitamin B6 supplementation
- Alcohol Use: Drinking alcohol during treatment increases the risk of liver injury and should be avoided
- Pediatric And Low Weight Dosing: This lower strength is often used for weight based dosing in children and smaller adults, and doses should never be adjusted without medical advice
- Drug Resistant TB: Missing doses or stopping treatment early can lead to isoniazid resistant tuberculosis, which is harder and costlier to treat
Isoniazid Tablet 100mg Side Effects
- Nausea and vomiting
- Loss of appetite
- Mild stomach discomfort
- Tingling or numbness in the hands and feet
- Fatigue
- Dizziness
- Skin rash
- Dark colored urine
- Yellowing of the skin or eyes
- Mild fever
Storage Conditions
- Store at room temperature, below 30°C
- Protect from moisture and direct sunlight
- Keep in the original pack until use
- Keep out of reach of children
- Discard any unused tablets after the expiry date
