About Isoniazid Tablet 300mg
Isoniazid Tablet 300mg contains isoniazid, a first line antitubercular drug used to treat active TB.
Isoniazid Tablet 300mg Uses
- Treats active pulmonary and extrapulmonary tuberculosis as part of combination therapy with rifampicin, pyrazinamide and ethambutol
- Used in the continuation phase of TB treatment alongside rifampicin after the initial intensive phase
- Prevents active tuberculosis in people with latent TB infection, especially close contacts of TB patients
- Used as preventive therapy in people with weakened immunity, including those living with HIV
Isoniazid Tablet 300mg Benefits
- Kills actively dividing TB bacteria quickly, helping reduce infectiousness within weeks of starting treatment
- Once daily dosing at this strength suits adults on standard weight based TB regimens
- Highly effective when taken as directed for the full treatment duration
- Widely available and affordable, supporting Pakistan's National TB Control Program
What Experts Say
Doctors prescribe isoniazid 300mg as part of the standard four drug regimen for active tuberculosis, since it kills fast growing TB bacteria more effectively than other first line drugs. The dose is calculated by body weight, and 300mg once daily suits most average weight adults, paired with rifampicin, pyrazinamide and ethambutol.
Because isoniazid can affect the liver, doctors monitor patients closely, especially those over 35 or with existing liver conditions. Physicians almost always prescribe vitamin B6, or pyridoxine, alongside isoniazid, since the drug depletes this vitamin and can cause numbness or tingling in the hands and feet.
Pakistan carries one of the highest tuberculosis burdens in the world, and isoniazid remains central to the national treatment strategy. Physicians stress that skipping doses or stopping early is a leading cause of drug resistant TB, so directly observed therapy helps ensure the full course is completed.
Drug Class
- Antitubercular agent
- Isonicotinic acid hydrazide derivative
Isoniazid Tablet 300mg Uses in Urdu
- فعال ٹی بی کے علاج کے لیے دیگر ادویات کے ساتھ استعمال ہوتی ہے
- ٹی بی کے مریضوں کے قریبی رابطے میں رہنے والے افراد میں بیماری سے بچاؤ کے لیے استعمال ہوتی ہے
- کمزور قوت مدافعت رکھنے والے افراد میں ٹی بی سے حفاظت کے لیے دی جاتی ہے
- پھیپھڑوں اور دیگر اعضاء کی ٹی بی کے علاج میں شامل کی جاتی ہے
Isoniazid Tablet 300mg formula
How to use Isoniazid Tablet 300mg?
- Take Isoniazid Tablet 300mg once daily, exactly as prescribed by your doctor
- Take on an empty stomach, at least one hour before or two hours after a meal, for best absorption
- Swallow the tablet whole with a full glass of water
- Take alongside vitamin B6 (pyridoxine) if prescribed, to help prevent nerve related side effects
- Complete the full course of treatment, even after symptoms improve, to prevent drug resistant TB
- Do not skip or double doses, and follow your directly observed therapy schedule if enrolled in Pakistan's National TB Control Program
- Avoid alcohol throughout the treatment period
Drug Interactions
- Phenytoin: Isoniazid raises phenytoin blood levels, increasing the risk of phenytoin toxicity, requiring dose adjustment and monitoring
- Rifampin: Combined use, though standard in TB regimens, increases the overall risk of liver toxicity and needs close monitoring
- Alcohol: Increases the risk of liver damage and should be avoided throughout treatment
- Paracetamol: Frequent or high dose use alongside isoniazid may raise the risk of liver injury
- Antacids: Aluminum containing antacids can reduce isoniazid absorption, so doses should be spaced apart
- Carbamazepine: Isoniazid can increase carbamazepine levels, raising the risk of side effects
Risks and warnings
- Liver Damage: Isoniazid can cause hepatotoxicity, ranging from mild transaminase elevation to severe hepatitis, especially in adults over 35 or those with existing liver disease
- Peripheral Neuropathy: Long term use can cause numbness, tingling or burning in the hands and feet due to vitamin B6 depletion, usually prevented by pyridoxine supplementation
- Alcohol Use: Drinking alcohol during treatment significantly raises the risk of liver injury and should be avoided
- Pregnancy And Breastfeeding: Use only under medical supervision, though isoniazid is generally considered safe when TB treatment is necessary
- Drug Resistant TB: Stopping treatment early or missing doses can lead to isoniazid resistant tuberculosis, a serious and harder to treat form of the disease
Isoniazid Tablet 300mg Side Effects
- Nausea and vomiting
- Loss of appetite
- Mild stomach upset
- Tingling or numbness in the hands and feet
- Fatigue and general weakness
- Dizziness
- Skin rash or itching
- Dark colored urine
- Yellowing of the skin or eyes, a sign of liver involvement
- Mild fever
Storage Conditions
- Store at room temperature, below 30°C
- Keep away from direct sunlight and moisture
- Store in the original pack until ready to use
- Keep out of reach of children
- Do not use after the expiry date printed on the pack
