Lukodermine Tablet 10mg

About Lukodermine Tablet 10mg

Lukodermine Tablet 10mg Uses

• Repigmentation of skin patches affected by idiopathic vitiligo, also called leucoderma
• Management of chronic plaque psoriasis alongside supervised UVA light sessions
• Restoring natural skin color in stable, non spreading vitiligo patches on the face, trunk and limbs

Drug Class

• Psoralen, a plant derived photosensitizing agent used in PUVA (Psoralen plus UVA) therapy

What Experts Say

Methoxsalen belongs to a group of natural compounds called psoralens. Once it reaches the skin, it makes the surface far more reactive to UVA light. Under a doctor's supervised UVA exposure, this reaction pushes dormant pigment cells in a vitiligo patch to start producing melanin again.

Vitiligo carries a heavy social burden in Pakistan, so many patients look for a repigmentation option beyond creams alone. Physicians pair this tablet with a fixed PUVA schedule, usually two to three sessions a week, and raise the light dose gradually as the skin tolerates it. Skipping doses or exposure sessions slows the response and can waste months of treatment.

Doctors always order baseline eye and liver checks before starting methoxsalen, since psoralens can affect both organs over time. Sunglasses that block UVA are mandatory on treatment days, even indoors near a window, to protect the lens from cataract risk. Regular follow up lets the treating doctor adjust the light dose and catch excess redness or blistering early.

Lukodermine Tablet 10mg formula

• Methoxsalen 10mg

Available forms

• Tablet

How to use Lukodermine Tablet 10mg?

• Take this tablet exactly at the time your dermatologist sets, usually two hours before the scheduled UVA session.
• Take it with milk or food to reduce stomach upset.
• Never expose skin to sunlight or UVA light outside the doctor supervised schedule.
• Wear UVA blocking sunglasses for the rest of the day after each dose.
• Do not double a missed dose before the next light session without medical advice.

Drug Interactions

• Tetracycline antibiotics: Raise photosensitivity further and increase burn risk during light sessions.
• Sulfonamide drugs: Add to the skin's sun sensitivity when combined with methoxsalen.
• Other photosensitizing agents: Retinoids, certain diuretics and some antidepressants can multiply the burn risk.
• Herbal photosensitizers: St John's Wort and similar herbal products intensify light reactions.

Risks and warnings

• Photosensitivity: Skin stays highly sensitive to light for hours after the dose, so unplanned sun exposure can cause severe burns.
• Eye risk: Long term psoralen use raises cataract risk if UVA blocking eyewear is skipped.
• Pregnancy and breastfeeding: Only used under specialist advice, since safety data in these groups is limited.
• Liver or kidney disease: Needs dose review, since methoxsalen is processed through the liver.
• Heart or blood pressure conditions: Requires caution because of possible low blood pressure and dizziness.
• Children: Not recommended for young children without direct dermatologist supervision.

Lukodermine Tablet 10mg Side Effects

• Nausea or mild stomach upset after the tablet
• Headache
• Burning or redness on light exposed skin
• Itching at the treated patch
• Dizziness or nervousness
• Sleep disturbance
• Low blood pressure with lightheadedness
• Blistering or severe sunburn from excess light exposure
• Eye irritation or blurred vision

Storage Conditions

• Store this tablet at room temperature, below 30 degrees Celsius.
• Keep the strip in its original box, away from direct sunlight.
• Keep it out of reach of children.
• Do not store in a bathroom cabinet where moisture is high.