Maxfol Tablet 400mg

About Maxfol Tablet 400mg

Maxfol Tablet Uses

• Prevention and treatment of folic acid deficiency and folate deficiency anemia.
• Prevention of neural tube defects in pregnant women and those planning pregnancy.
• Reduction of elevated homocysteine levels reducing cardiovascular risk.
• Megaloblastic and macrocytic anemia management due to folate deficiency.
• Support for cognitive function and mood in patients with low folate status.

Maxfol Tablet Benefits

• Essential vitamin B9 form required for DNA synthesis and cell division.
• Supports red blood cell formation and maturation preventing anemia.
• Reduces homocysteine levels providing cardiovascular protection.
• Critical for fetal development and prevention of birth defects in pregnancy.
• Well-tolerated with minimal adverse effects at recommended doses.

What Experts Say

Folic acid is the synthetic form of folate, a water-soluble B vitamin essential for cellular function. Folic acid converts in the body to tetrahydrofolic acid (THF), the biologically active form. THF serves as a cofactor in one-carbon metabolism participating in methylation and nucleotide synthesis reactions. These reactions are critical for DNA synthesis and repair, cell division, and amino acid metabolism. Folic acid's role in DNA synthesis makes it particularly important during periods of rapid cell growth including fetal development and erythropoiesis.

Pharmacokinetically, folic acid demonstrates rapid absorption in the small intestine reaching peak plasma concentrations within 1 to 2 hours. The drug undergoes hepatic conversion to active metabolites. Approximately 80 percent of the body's folate is stored in the liver with smaller amounts in tissues. Folate excretion occurs primarily via the kidneys. Steady-state concentrations reflect dietary intake and body stores. Deficiency develops when stores are depleted through inadequate intake or increased utilization.

Clinical efficacy data demonstrates folic acid supplementation effectively corrects deficiency and prevents associated anemia. Large prospective studies show folic acid supplementation reduces neural tube defect risk by 50 to 70 percent in women consuming adequate doses during periconception period. Folic acid reduces elevated homocysteine levels which are associated with increased cardiovascular disease risk. Long-term supplementation studies support safety and efficacy for pregnancy, cognitive support, and mood in deficient populations.

Drug Class

• Vitamin B9 Supplement, Water-Soluble Vitamin

Packaging and Quantity

• Blister strip or bottle containing 30 tablets of 400 mcg or 600 mcg each.

When Not to Use Maxfol

• Known hypersensitivity to folic acid or any component of the formulation.
• Untreated vitamin B12 deficiency as folic acid may mask neurological symptoms.
• Certain malignancies actively treated with methotrexate.
• Severe anemia of unknown etiology without medical evaluation.

Maxfol Tablet 400mg formula

• Folic acid

Available forms

• Tablets

How to use Maxfol Tablet 400mg?

• Take orally once daily as directed by your healthcare provider.
• Typical dose for folic acid deficiency is 400 to 800 mcg once daily.
• For pregnancy prevention of neural tube defects, dose is 400 to 1000 mcg daily starting one month before conception.
• For elevated homocysteine, dose is 400 to 1000 mcg daily.
• Swallow tablet whole with a full glass of water.
• Can be taken with or without food preferably at the same time each day.

Drug Interactions

Maxfol may interact with various medications affecting efficacy or safety:

• Methotrexate: Folic acid may reduce methotrexate efficacy; timing of administration should be coordinated with healthcare provider.
• Phenytoin and other anticonvulsants: These drugs may impair folic acid metabolism; supplementation may be needed.
• Trimethoprim and sulfonamides: These antibiotics inhibit folate metabolism; supplementation may increase effectiveness.
• Alcohol: Chronic alcohol use impairs folic acid absorption and metabolism; avoid excessive alcohol.

Risks and warnings

• Vitamin B12 deficiency: Folic acid may mask neurological symptoms of B12 deficiency; evaluate B12 status before supplementing.
• Pernicious anemia: Folic acid supplementation without B12 treatment may worsen neurological complications.
• Methotrexate therapy: Timing of folic acid administration is critical; coordinate with oncologist.
• Pregnancy: Folic acid is safe and recommended during pregnancy especially at doses of 400 to 1000 mcg daily.
• Breastfeeding: Folic acid is excreted in breast milk; safe to use during breastfeeding.
• Alcohol consumption: Chronic alcohol use increases folate requirements; abstinence improves supplementation effectiveness.
• Dietary sources: Consumption of folate-rich foods including leafy greens, legumes, and fortified grains complements supplementation.

Maxfol Tablet Side Effects

Folic acid is generally well-tolerated with minimal adverse effects. Following are rarely reported adverse effects:

• Nausea or loss of appetite.
• Mild gastrointestinal discomfort.
• Sleep disturbances or irritability.
• Mild rash or itching.

Serious side effects requiring immediate medical attention:

• Severe allergic reaction with rash or angioedema.
• Unusual bruising or bleeding.
• Neurological symptoms if B12 deficiency is masked.

Storage Conditions

• Store at room temperature below 25 degrees Celsius.
• Keep away from direct sunlight and excessive heat.
• Protect from moisture in a tightly sealed container.
• Keep in original blister strip or tablet container.
• Keep out of reach of children and pets.
• Do not use after the expiration date on the packaging.