Medigesic Tablet 35mg / 450mg

About Medigesic Tablet 35mg / 450mg

Medigesic Tablet 35mg / 450mg Uses

• Muscle pain and spasm relief
• Musculoskeletal conditions such as sprains and strains
• Back pain and neck pain associated with muscle tightness
• Pain relief alongside rest and physiotherapy

Medigesic Tablet 35mg / 450mg Benefits

• Combines a muscle relaxant with a pain reliever in one tablet
• Helps ease stiffness so daily movement becomes easier
• Paracetamol component also helps lower fever if present
• Convenient dosing compared with taking two separate medicines

What Experts Say

Orphenadrine Citrate works centrally to reduce muscle spasm, while Paracetamol adds analgesic and mild antipyretic action, so the combination addresses both the muscle tightness and the pain it produces. This dual approach is a common first step for short term musculoskeletal pain before stronger agents are considered.

Physicians usually limit this combination to short courses, since Orphenadrine has anticholinergic properties that can cause dry mouth, blurred vision or drowsiness with prolonged use. Elderly patients and those with glaucoma or an enlarged prostate are monitored more closely for these effects.

Musculoskeletal pain is one of the most common reasons patients in Pakistan seek outpatient care, often linked to physical labor, poor posture or lack of regular exercise. This fixed-dose tablet remains a practical option when rest and physiotherapy alone do not fully relieve muscle-related discomfort.

Drug Class

• Skeletal Muscle Relaxant
• Analgesic
• Antipyretic

Medigesic Tablet 35mg / 450mg formula

• Orphenadrine Citrate + Paracetamol

Available forms

• Tablet

How to use Medigesic Tablet 35mg / 450mg?

• Take one tablet by mouth two to three times daily, or as directed by your doctor
• Swallow the tablet with a glass of water
• Take after meals to reduce stomach upset
• Do not exceed the dose or duration advised by your doctor
• Avoid driving or operating machinery until you know how the tablet affects you

Drug Interactions

• Sedatives: Increases drowsiness when combined with sleep aids or anti-anxiety medicines
• Anticholinergic Drugs: Combined use can worsen dry mouth, blurred vision and urinary retention
• Warfarin: Paracetamol can enhance the blood-thinning effect with prolonged combined use
• Alcohol: Raises the risk of liver toxicity and sedation
• Other Paracetamol-Containing Products: Avoid combining to prevent accidental overdose

Risks and warnings

• Liver Disease: Use with caution, since Paracetamol overdose is a leading cause of liver injury
• Glaucoma: Orphenadrine can raise eye pressure and is not recommended for patients with narrow angle glaucoma
• Enlarged Prostate: May worsen urinary retention in men with prostate enlargement
• Drowsiness: Can cause dizziness or sedation, use caution when driving
• Pregnancy: Use only if clearly needed and advised by a doctor
• Alcohol: Avoid alcohol, as it increases sedation and liver strain

Medigesic Tablet 35mg / 450mg Side Effects

• Dry mouth
• Drowsiness
• Dizziness
• Blurred vision
• Nausea
• Constipation
• Difficulty urinating
• Rapid heartbeat
• Skin rash in rare cases

Storage Conditions

• Store below 30°C in a cool, dry place
• Keep the tablet in its original blister pack away from moisture
• Protect from direct sunlight and heat
• Keep out of reach of children