Nepra Tablet 500mg

About Nepra Tablet 500mg

Nepra Tablet 500mg Uses

• Relieves mild to moderate pain from headaches, backache and toothache
• Eases joint pain and stiffness in osteoarthritis and rheumatoid arthritis
• Reduces menstrual cramps and muscular pain
• Controls fever and inflammation linked to minor injuries
• Manages pain flares in ankylosing spondylitis and gout attacks

Nepra Tablet 500mg Benefits

• Provides longer lasting pain relief than shorter acting NSAIDs
• Twice daily dosing improves convenience for chronic pain patients
• Reduces swelling alongside pain, helpful during arthritis flares
• Available at an affordable price for households across Pakistan

What Experts Say

Naproxen belongs to the propionic acid group of nonsteroidal anti-inflammatory drugs, a class widely used across Pakistan for pain and inflammation. It blocks cyclooxygenase enzymes that produce prostaglandins, chemicals responsible for pain, swelling and fever.

Clinical guidelines list naproxen as a preferred option for chronic joint conditions because of its steady effect over roughly 8 to 12 hours per dose. Doctors still caution that regular use carries meaningful stomach, kidney and cardiovascular risks, especially in older adults or those with existing heart disease or ulcer history.

Experts generally recommend the lowest effective dose for the shortest possible duration needed to control symptoms. Patients with a history of ulcers, kidney disease or heart conditions need medical supervision before starting naproxen, since it can worsen these underlying conditions if used without monitoring.

Drug Class

• Nonsteroidal Anti-Inflammatory Drug (NSAID)
• Propionic Acid Derivative

Nepra Tablet 500mg formula

• Naproxen

Available forms

• Tablet

How to use Nepra Tablet 500mg?

• Take with food or milk to reduce stomach irritation
• Swallow the tablet whole with a full glass of water
• Use the lowest effective dose for the shortest duration needed
• Do not crush or split the tablet unless advised by a doctor
• Avoid lying down for at least 10 minutes after taking the dose

Drug Interactions

• Aspirin and Other NSAIDs: Combined use raises the risk of stomach bleeding without added pain relief.
• Blood Thinners (Warfarin): Naproxen increases bleeding risk when taken with anticoagulants.
• ACE Inhibitors and Diuretics: Naproxen can reduce their effectiveness and strain kidney function.
• Lithium: Naproxen can raise lithium levels in the blood, leading to toxicity.
• Corticosteroids: Combined use further increases the risk of gastrointestinal ulcers.

Risks and warnings

• Cardiovascular Risk: Long term use may raise the risk of heart attack or stroke, particularly in patients with existing heart disease.
• Gastrointestinal Risk: Naproxen can cause stomach ulcers or bleeding, which may occur without warning symptoms.
• Kidney Function: Use with caution in patients with reduced kidney function or those on diuretics.
• Pregnancy: Avoid during the third trimester due to risk of complications for the baby.
• Asthma: Patients with aspirin sensitive asthma may experience worsened breathing symptoms.

Nepra Tablet 500mg Side Effects

• Stomach upset, heartburn or nausea
• Headache or dizziness
• Drowsiness
• Fluid retention or mild swelling in the legs
• Ringing in the ears with high doses
• Stomach ulcers or gastrointestinal bleeding with long term use
• Signs of kidney problems such as reduced urination or swelling
• Chest pain, shortness of breath or signs of a heart attack
• Severe allergic reaction with rash, swelling or breathing difficulty

Storage Conditions

• Store below 30°C in a cool dry place
• Keep away from direct sunlight and moisture
• Keep out of reach of children
• Do not use after the expiry date printed on the pack