Olesta AM Tablet 5mg / 40mg

About Olesta AM Tablet 5mg / 40mg

Olesta AM Tablet 5mg / 40mg Uses

• High blood pressure (hypertension)
• Hypertension not controlled by amlodipine or olmesartan alone
• Reducing cardiovascular risk associated with high blood pressure

Olesta AM Tablet 5mg / 40mg Benefits

• Combines two complementary mechanisms for stronger blood pressure control
• Once daily dosing supports better treatment adherence
• Higher olmesartan dose suits patients needing more aggressive control

What Experts Say

Amlodipine is a dihydropyridine calcium channel blocker that relaxes vascular smooth muscle by limiting calcium entry into arterial cell walls. This action lowers peripheral vascular resistance and produces a steady blood pressure reduction across a full 24 hour period, since amlodipine has a long elimination half life and a gradual onset of action.

Olmesartan medoxomil is an angiotensin II receptor blocker that binds the AT1 receptor and prevents angiotensin II from triggering vasoconstriction and aldosterone release. Blocking this pathway lowers blood pressure while easing the workload on the heart and reducing pressure related strain on the kidneys over the long term.

Doctors reserve the 5mg / 40mg strength for patients whose blood pressure stays above target on lower dose combinations, since the higher olmesartan component gives stronger renin angiotensin suppression. Pairing a calcium channel blocker with an angiotensin receptor blocker also blunts the ankle swelling amlodipine can cause alone, since the two drugs offset each other's fluid effects.

Drug Class

• Calcium Channel Blocker (Amlodipine)
• Angiotensin II Receptor Blocker (Olmesartan Medoxomil)

Olesta AM Tablet 5mg / 40mg formula

• Amlodipine + Olmesartan Medoxomil

Available forms

• Tablet

How to use Olesta AM Tablet 5mg / 40mg?

• Take one tablet by mouth once daily, with or without food
• Swallow the tablet whole with a glass of water
• Take at the same time each day for consistent blood pressure control
• Do not stop taking without consulting your doctor, even if you feel well

Drug Interactions

• Potassium Sparing Diuretics: Combining with olmesartan can raise potassium levels excessively
• NSAIDs: May reduce the blood pressure lowering effect and increase the risk of kidney problems
• Lithium: ARBs can raise lithium levels and increase the risk of toxicity
• Simvastatin: Amlodipine can raise simvastatin levels, increasing muscle related side effects
• Other Antihypertensives: May cause an additive blood pressure lowering effect requiring dose adjustment

Risks and warnings

• Pregnancy: Avoid use during pregnancy, as olmesartan can cause fetal injury and death
• Low Blood Pressure: May cause symptomatic hypotension, especially after the first dose or a dose increase
• Kidney Function: Use with caution in patients with kidney impairment, as ARBs can affect renal blood flow
• Liver Disease: Use cautiously in patients with severe liver impairment
• Heart Conditions: Use with caution in patients with severe aortic stenosis or unstable heart failure

Olesta AM Tablet 5mg / 40mg Side Effects

• Swelling in the ankles or feet
• Dizziness or lightheadedness
• Headache
• Fatigue
• Flushing
• Nausea
• Low blood pressure
• Diarrhea
• Muscle cramps
• Palpitations

Storage Conditions

• Store below 30°C in a cool, dry place
• Keep the tablets in their original blister pack until use
• Protect from direct sunlight and moisture
• Keep out of reach of children