Pletaal Tablet 100mg

About Pletaal Tablet 100mg

Pletaal Tablet 100mg Uses

• Treating intermittent claudication (leg pain while walking) caused by peripheral arterial disease
• Improving walking distance in people with reduced blood flow to the legs
• Supporting circulation in diagnosed peripheral vascular disease
• Used alongside lifestyle changes such as walking programs and quitting smoking

Pletaal Tablet 100mg Benefits

• Increases pain free and maximum walking distance over time
• Improves blood flow to the leg muscles
• Provides mild antiplatelet protection against clot formation
• Offers a non-opioid option for claudication related leg pain

What Experts Say

Cilostazol works by blocking phosphodiesterase III, an enzyme that normally breaks down cyclic AMP inside platelets and blood vessel walls. Higher cyclic AMP levels reduce platelet clumping and relax smooth muscle in artery walls at the same time.

This dual action explains why cilostazol helps intermittent claudication more consistently than a plain antiplatelet drug alone. Clinical trials show it can meaningfully increase pain free and maximum walking distance within 4 to 12 weeks of regular use, unlike drugs that only thin the blood.

The same phosphodiesterase III mechanism is why cilostazol is avoided in heart failure of any severity. Other drugs in this class have been linked to higher mortality when heart pumping function is already reduced, so cardiologists screen for this before prescribing. Its antiplatelet effect is reversible and typically clears from the body within 48 to 96 hours, a detail doctors factor in when planning surgery or dental procedures.

Drug Class

• Phosphodiesterase III (PDE3) Inhibitor
• Antiplatelet Agent
• Vasodilator

Pletaal Tablet 100mg formula

• Cilostazol

Available forms

• Tablet

How to use Pletaal Tablet 100mg?

• Take one 100mg tablet twice daily, or as prescribed by your doctor
• Take on an empty stomach, at least 30 minutes before or 2 hours after meals
• Swallow the tablet whole with a glass of water
• Take at the same times each day for consistent blood levels
• Continue for the full duration your doctor recommends, even if symptoms improve
• Do not double the dose if you miss one, just take the next dose as scheduled

Drug Interactions

• CYP3A4 Inhibitors (Ketoconazole, Itraconazole, Erythromycin, Diltiazem): Raise cilostazol blood levels significantly, a dose reduction to 50mg twice daily is usually needed.
• CYP2C19 Inhibitors (Omeprazole): Increase levels of the active metabolite, requiring closer monitoring.
• Aspirin and Other Antiplatelets: Combined use adds to bleeding risk, monitor for unusual bruising.
• Grapefruit Juice: May raise cilostazol levels through the same enzyme pathway, best avoided during treatment.

Risks and warnings

• Heart Failure Warning: Cilostazol is not recommended for patients with any degree of heart failure, since similar drugs have been linked to higher mortality in this group.
• Bleeding Risk: Increases bleeding tendency, use caution with other blood thinning medicines or before surgery.
• Blood Disorders: Rare cases of low platelet or white blood cell counts have been reported, report unusual bruising or infection promptly.
• Pregnancy and Breastfeeding: Safety is not well established, use only if your doctor considers it necessary.

Pletaal Tablet 100mg Side Effects

• Headache
• Diarrhea
• Abnormal or loose stools
• Palpitations or a fast heartbeat
• Dizziness
• Indigestion
• Runny nose
• Easy bruising or unusual bleeding
• Swelling in the legs or feet
• Irregular heartbeat needing urgent care
• Signs of infection such as fever or sore throat needing urgent care

Storage Conditions

• Store below 30°C in a cool, dry place away from direct sunlight
• Keep the tablets in their original blister strip until ready to use
• Keep out of reach of children
• Do not use beyond the expiry date printed on the pack