About Pletaal Tablet 50mg
Cilostazol tablet that improves blood flow and walking distance in peripheral artery disease.
Pletaal Tablet Uses
- Treatment of intermittent claudication in peripheral artery disease
- Relief of leg pain and cramping that occurs during walking
- Long term management of reduced blood flow in the legs
- Support for patients who cannot tolerate surgical revascularization
Pletaal Tablet Benefits
- Increases pain free and total walking distance over time
- Widens blood vessels in the legs to improve circulation
- Reduces platelet clumping, lowering the risk of clot formation
- Improves daily mobility and quality of life in PAD patients
What Experts Say
Cilostazol works by inhibiting phosphodiesterase III, which raises cyclic AMP levels inside platelets and vascular smooth muscle cells. This dual action reduces platelet aggregation while relaxing blood vessels, together improving blood flow to the legs during exertion.
Physicians typically prescribe Cilostazol at 100mg twice daily, reserving the 50mg strength for patients who need a lower starting dose or who are taking medicines that slow its breakdown. Vascular specialists caution that visible improvement in walking distance can take several weeks of consistent use, so early discontinuation is a common reason for perceived treatment failure.
Because Cilostazol carries a documented mortality signal in patients with heart failure, prescribers screen cardiac history carefully before starting therapy and avoid the drug in anyone with reduced heart pump function. Regular follow up also checks for bleeding tendencies, since the antiplatelet effect can add to the risk from aspirin or other blood thinners taken for the same vascular condition.
Drug Class
- Phosphodiesterase III inhibitor
- Antiplatelet and vasodilator agent
Pletaal Tablet 50mg Uses in Urdu
- ٹانگوں میں خون کی روانی کم ہونے کی وجہ سے چلنے پر درد یا اینٹھن کا علاج
- پیریفرل آرٹری ڈیزیز کی علامات میں کمی
- چلنے کی صلاحیت اور فاصلے میں بہتری
- خون کے پلیٹلیٹس کو آپس میں چپکنے سے روکنا
Pletaal Tablet 50mg formula
How to use Pletaal Tablet 50mg?
- Take Pletaal Tablet 50mg on an empty stomach, at least 30 minutes before or 2 hours after meals
- Take one tablet twice daily, in the morning and evening, unless the doctor advises otherwise
- Swallow the tablet whole with a glass of water, do not crush or chew it
- Continue treatment for the full duration prescribed even if walking distance has not improved yet
- Avoid grapefruit juice while taking this medicine
- Do not stop the medicine suddenly without consulting the prescribing doctor
Drug Interactions
- Ketoconazole And Other Strong CYP3A4 Inhibitors: Raise Cilostazol blood levels significantly and require a lower dose
- Omeprazole And Other CYP2C19 Inhibitors: Increase active drug exposure, requiring closer monitoring
- Diltiazem: Moderately raises Cilostazol levels through CYP3A4 inhibition
- Aspirin, Clopidogrel And Anticoagulants: Combined use raises the overall risk of bleeding
- Grapefruit Juice: Can increase Cilostazol absorption and should be avoided
Risks and warnings
- Heart Failure: Cilostazol is contraindicated in patients with any grade of congestive heart failure because phosphodiesterase III inhibitors have been linked to reduced survival in this group
- Bleeding Risk: The antiplatelet effect can increase bruising and bleeding, especially when combined with aspirin, clopidogrel or anticoagulants
- Cardiac History: Use with caution in patients with a history of arrhythmia, angina or a recent heart attack
- Liver Or Kidney Impairment: Dose adjustment or avoidance may be needed since Cilostazol is metabolized by the liver and cleared partly by the kidneys
- Pregnancy And Breastfeeding: Not recommended unless clearly needed, since safety data in pregnant and breastfeeding women is limited
Pletaal Tablet Side Effects
- Headache
- Diarrhea
- Abnormal or loose stools
- Dizziness
- Palpitations or a fast heartbeat
- Peripheral edema (swelling in the feet or ankles)
- Nausea
- Rash
- Easy bruising or unusual bleeding
- Sore throat or signs of infection in rare cases
Storage Conditions
- Store below 30°C in a cool, dry place away from direct sunlight
- Keep the tablets in their original blister pack until the dose is due
- Keep out of reach of children
- Do not use after the expiry date printed on the pack
