Pofol Injection 200mg

About Pofol Injection 200mg

Pofol Injection 200mg Uses

• Induction of general anesthesia before surgery
• Maintenance of general anesthesia during surgical procedures
• Sedation for patients undergoing diagnostic or minor surgical procedures
• Continuous sedation for patients on mechanical ventilation in intensive care

Drug Class

• General anesthetic (intravenous)

What Experts Say

Propofol is a short acting intravenous anesthetic that works by enhancing GABA, the brain's main inhibitory neurotransmitter, producing sedation within about thirty seconds of injection. Its rapid onset and equally quick recovery profile make it a preferred agent for procedures that need fast induction and a fast, clear headed wake up.

Anesthesia teams value propofol for its favorable recovery profile compared with older induction agents, though it carries a well documented risk of dose dependent low blood pressure and slowed breathing. Continuous infusion for prolonged intensive care sedation needs close monitoring of triglyceride levels, since the drug is formulated in a lipid emulsion base.

Because propofol has no pain relieving effect on its own, it is usually combined with an opioid or a regional anesthesia technique during surgery. Strict aseptic handling is essential once a vial is opened, since the lipid base can support rapid bacterial growth at room temperature, so hospitals follow dedicated protocols for storage, dilution and disposal.

Pofol Injection 200mg formula

• Propofol 200mg/20ml (1% w/v)

Available forms

• Injection

How to use Pofol Injection 200mg?

• Administered only by an anesthesiologist or other trained medical professional in a hospital or clinical setting.
• Given as a slow intravenous injection or continuous infusion, with dose calculated by body weight and procedure type.
• Never self administered or used outside a monitored medical facility.
• Requires continuous monitoring of heart rate, blood pressure and oxygen levels during and after administration.
• Vial must be used immediately once opened and any unused portion discarded.

Drug Interactions

• Opioids: Combined use increases the risk of profound sedation and slowed breathing.
• Benzodiazepines: Additive sedative effect raises the risk of respiratory depression.
• Other anesthetic agents: Can enhance central nervous system depression when combined.
• Alcohol: Increases sedative effect if used before or shortly after anesthesia.
• Blood pressure medicines: May worsen the blood pressure drop caused by propofol.

Risks and warnings

• Hospital use only: Must be given by trained anesthesia personnel with resuscitation equipment available.
• Blood pressure drop: Can cause a significant fall in blood pressure, especially in elderly or unstable patients.
• Breathing suppression: May slow or stop breathing, requiring airway support equipment on standby.
• Egg or soy allergy: Contains egg lecithin and soybean oil, avoid in patients with a known allergy to these.
• Propofol infusion syndrome: Rare but serious complication linked to prolonged high dose infusion, more common in children.
• Pregnancy and breastfeeding: Use only when a doctor determines the benefit outweighs the risk.

Pofol Injection 200mg Side Effects

• Pain or burning at the injection site
• Low blood pressure
• Slowed breathing
• Involuntary muscle movements during induction
• Headache after waking
• Nausea or vomiting on recovery
• Irregular heartbeat (uncommon)
• Severe allergic reaction such as swelling or difficulty breathing (rare)

Storage Conditions

Store between 2°C and 25°C, protect from light and freezing, and use immediately once opened, discarding any unused portion.