Pofol Injection 1%

About Pofol Injection 1%

Pofol Injection 1% Uses

• Induction of general anesthesia before surgery
• Maintenance of general anesthesia during surgical procedures
• Sedation for patients on mechanical ventilation in intensive care
• Sedation during minor procedures performed outside the operating room

Drug Class

• General anesthetic (sedative hypnotic agent)

What Experts Say

Propofol works on the brain's gamma aminobutyric acid receptors to slow nerve activity and bring on a calm, sleep like state within seconds of injection. Anesthesiologists value this quick onset because it lets a surgical team begin a procedure with minimal delay. The effect wears off fast once the infusion stops, helping patients wake up clearly.

Every dose is calculated for the individual patient based on weight, age, and overall health status. A trained anesthesia provider continuously adjusts the infusion rate while watching heart rate, blood pressure, and oxygen levels. This close monitoring is why Propofol is only given inside a hospital or a properly equipped procedure room.

Extended high dose use in intensive care carries a rare but serious risk known as propofol infusion syndrome, which can affect the heart and muscles. Doctors watch for this risk during prolonged sedation and adjust the dose if warning signs appear. Because of these risks, Propofol stays firmly in the category of medicines that only qualified medical staff can prepare and give.

Pofol Injection 1% formula

• Propofol 200mg/20ml (1% w/v)

Available forms

• Injection

How to use Pofol Injection 1%?

• Administered only by a doctor, anesthesiologist, or trained hospital staff in a monitored clinical setting.
• Given as a slow intravenous injection or continuous infusion, never as a home or self administered medicine.
• Dose is calculated individually based on body weight, age, and the type of procedure.
• Continuous monitoring of heart rate, breathing, and blood pressure is required during and after administration.
• Not for use outside a hospital, clinic, or properly equipped procedure room.

Drug Interactions

• Opioid painkillers: Combined use increases the risk of slowed breathing and deep sedation.
• Benzodiazepines: Additive sedative effect raises the risk of excessive drowsiness and breathing problems.
• Other anesthetic agents: Using multiple sedatives together needs careful dose adjustment by the anesthesia team.
• Blood pressure medicines: May add to the blood pressure lowering effect of Propofol.
• Alcohol: Increases sedation and should be avoided for at least 24 hours after the procedure.

Risks and warnings

• Hospital use only: This injection must never be self administered or used outside a monitored medical setting.
• Propofol infusion syndrome: A rare but serious complication linked to high dose, prolonged ICU sedation.
• Allergy risk: Avoid in patients with a known allergy to soy, egg products, or Propofol itself, since the injection is an oil in water emulsion.
• Cardiovascular effects: Can lower blood pressure and slow breathing, requiring trained staff to manage the airway.
• Pregnancy and breastfeeding: Use only when a doctor judges the benefit outweighs the risk.
• Elderly and critically ill patients: Often need a lower dose and closer monitoring due to higher sensitivity.

Pofol Injection 1% Side Effects

• Pain or stinging at the injection site
• Low blood pressure
• Slowed or shallow breathing
• Drowsiness lasting longer than expected
• Headache after waking
• Nausea or vomiting
• Irregular heartbeat (rare)
• Severe allergic reaction such as rash, swelling, or difficulty breathing (rare)

Storage Conditions

Store below 25°C, protected from light and freezing. Once opened, use immediately and discard any unused portion. Keep out of reach of children. For hospital and clinical use only.