About Probase Tablet 5mg
Probase Tablet contains Bisoprolol, a beta blocker, used for high blood pressure and heart conditions.
Probase Tablet Uses
- Management of high blood pressure (hypertension)
- Long term treatment of stable chronic heart failure
- Prevention of angina (chest pain) episodes
- Control of certain irregular heart rhythms
Probase Tablet Benefits
- Lowers the heart's workload by slowing heart rate
- Reduces blood pressure and eases strain on blood vessels
- Helps prevent complications like stroke and heart attack
- Improves survival outcomes in patients with heart failure
What Experts Say
Bisoprolol is a cardioselective beta-1 adrenergic receptor blocker. It works mainly on beta-1 receptors in the heart, reducing the influence of adrenaline and noradrenaline on cardiac tissue. This selectivity lowers resting heart rate, reduces contraction force, and decreases cardiac output, lowering blood pressure and cutting the oxygen demand of the heart muscle.
Because bisoprolol has minimal effect on beta-2 receptors found in the lungs and blood vessels at standard doses, it carries a lower risk of triggering bronchospasm compared with non-selective beta blockers. Clinical evidence supports its long term use in chronic heart failure, where it reduces the harmful effects of sustained sympathetic nervous system activation on the heart.
The drug's long half-life allows once daily dosing, which supports consistent blood levels and better adherence. Pharmacological studies confirm that gradual dose titration is essential when starting therapy in heart failure patients, since an abrupt full dose can initially worsen cardiac function before the protective benefits take effect.
Drug Class
- Beta-1 Selective Adrenergic Receptor Blocker (Cardioselective Beta Blocker)
Probase Tablet 5mg Uses in Urdu
- ہائی بلڈ پریشر کو کنٹرول کرنے کے لیے
- دل کی دائمی کمزوری (ہارٹ فیلیئر) کے علاج میں
- سینے کی جکڑن اور انجائنا کی روک تھام کے لیے
- دل کی بے ترتیب دھڑکن کو منظم کرنے کے لیے
Probase Tablet 5mg formula
How to use Probase Tablet 5mg?
- Take this tablet once daily in the morning with or without food.
- Swallow the tablet whole with a glass of water.
- Take the dose at the same time each day to maintain steady blood levels.
- Do not stop the medicine abruptly without consulting your doctor.
- Take a missed dose as soon as remembered unless it is almost time for the next dose.
Drug Interactions
- Verapamil And Diltiazem: Combining these calcium channel blockers with bisoprolol raises the risk of severe bradycardia and atrioventricular block.
- Digoxin: Concurrent use can further slow the heart rate and increase the risk of conduction disturbances.
- Clonidine: Stopping clonidine while still on bisoprolol can cause a dangerous rebound rise in blood pressure.
- Insulin And Oral Antidiabetics: Bisoprolol can mask warning signs of low blood sugar such as a racing heartbeat.
- NSAIDs: Regular use of nonsteroidal anti-inflammatory drugs can reduce the blood pressure lowering effect of bisoprolol.
- Other Antihypertensives: Combining with other blood pressure lowering drugs increases the risk of excessive hypotension.
Risks and warnings
- Abrupt Discontinuation: Stopping this medicine suddenly can worsen chest pain or trigger a heart attack in patients with coronary artery disease.
- Bronchospasm Risk: Use with caution in patients with asthma or chronic obstructive pulmonary disease since beta blockade can trigger breathing difficulty.
- Masked Hypoglycemia: Diabetic patients may not notice a fast heartbeat as a warning sign of low blood sugar while taking this medicine.
- Heart Block: Avoid use in patients with severe bradycardia or advanced atrioventricular block unless a pacemaker is fitted.
- Anesthesia Caution: Inform the surgical team before any operation since this medicine can affect the heart's response during anesthesia.
Probase Tablet Side Effects
- Fatigue and tiredness
- Dizziness or lightheadedness
- Cold hands and feet
- Slow heart rate (bradycardia)
- Low blood pressure
- Headache
- Nausea or upset stomach
- Sleep disturbances including vivid dreams
- Shortness of breath in susceptible patients
- Worsening of heart failure symptoms if the dose is increased too quickly
Storage Conditions
- Store below 30°C in a cool, dry place away from direct sunlight.
- Keep the tablets in their original blister pack until ready to use.
- Keep out of reach of children.
- Protect from moisture and humidity.
- Discard any unused tablets after the expiry date printed on the pack.
