Spasler-P Syrup 5mg/5ml

About Spasler-P Syrup 5mg/5ml

Spasler-P Syrup Uses

• Abdominal cramps and spasmodic pain caused by gastrointestinal conditions.
• Irritable bowel syndrome (IBS) presenting with abdominal pain, bloating, and altered bowel habits.
• Bowel colic and intestinal spasms caused by gastroenteritis or functional gut disorders.
• Biliary colic caused by gallstone movement through the bile ducts.
• Spasms of the urinary tract including bladder spasms, urinary urgency, and painful urination.
• Ureteric colic associated with kidney stone passage.
• Menstrual cramps (primary dysmenorrhea) causing uterine spasms.
• Spasms associated with endoscopic procedures including colonoscopy and gastroscopy.
• Palliative care: reduction of painful smooth muscle spasms in terminal illness.

Spasler-P Syrup Benefits

• Provides rapid relief from smooth muscle spasms with onset within 15 to 30 minutes of taking the dose.
• Does not cross the blood-brain barrier at therapeutic doses in oral form, meaning it does not cause significant sedation during daytime use.
• Liquid formulation makes it suitable for children above 6 years and patients who have difficulty swallowing tablets.
• Targets spasms across multiple body systems, including the gut, bile ducts, and urinary tract, with a single medicine.
• Suitable for use alongside other medicines without significant pharmacokinetic drug interactions.

What Experts Say

Spasler-P contains Hyoscine Butylbromide, a quaternary ammonium anticholinergic agent with targeted action on smooth muscle tissue in the visceral organs.

How It Works

Hyoscine Butylbromide works by competitively blocking muscarinic acetylcholine receptors (M1, M2, and M3 subtypes) in the smooth muscle of the gastrointestinal tract, bile ducts, and urinary system. Acetylcholine normally binds to these receptors to stimulate smooth muscle contraction. By occupying the receptor without activating it, Hyoscine Butylbromide prevents this contraction signal, causing the smooth muscle to relax and reducing the frequency and intensity of spasms. It also binds to nicotinic receptors in autonomic ganglia, producing a mild ganglion-blocking effect that contributes to its antispasmodic action.

Why It Does Not Cause Sedation

Unlike Hyoscine Hydrobromide (the base form used for motion sickness), Hyoscine Butylbromide carries a positively charged quaternary ammonium group that prevents it from crossing the blood-brain barrier at therapeutic oral doses. This means its anticholinergic effects are largely restricted to peripheral tissues, producing smooth muscle relaxation without the CNS effects of sedation, confusion, or cognitive impairment that characterize centrally acting anticholinergics. This peripheral selectivity makes Spasler-P safe for daytime use and suitable for children above 6 years.

Clinical Note

Hyoscine Butylbromide treats the symptom of spasm rather than the underlying cause. In patients with persistent or severe abdominal pain, a diagnosis must be established before initiating antispasmodic therapy, as masking pain with Spasler-P can delay identification of serious conditions such as appendicitis, intestinal obstruction, or bowel perforation. In patients with ulcerative colitis, Hyoscine Butylbromide must be used with caution as it can precipitate toxic megacolon by reducing gut motility.

Drug Class

• Anticholinergic Antispasmodic.
• Quaternary Ammonium Compound.

Packaging and Quantity

• 60ml syrup bottle.
• Each 5ml contains Hyoscine Butylbromide 5mg.
• A measuring cup is included with each bottle.

When Not to Use Spasler-P

• Known allergy or hypersensitivity to Hyoscine Butylbromide or any anticholinergic medicine.
• Myasthenia gravis, as anticholinergic medicines worsen neuromuscular transmission.
• Acute narrow-angle glaucoma, as anticholinergic effects can raise intraocular pressure.
• Megacolon or paralytic ileus, as reducing gut motility can worsen these conditions.
• Severe ulcerative colitis, due to the risk of toxic megacolon.
• Urinary retention or symptomatic prostatic hypertrophy.

Tachycardia or significant cardiac arrhythmia.

Spasler-P Syrup 5mg/5ml formula

• Hyoscine

Available forms

• Syrup

How to use Spasler-P Syrup 5mg/5ml?

• Shake the bottle well before every dose.
• Use the measuring cup provided to ensure accurate dosing.
• Spasler-P may be taken with or without food.
• A doctor should be consulted if pain is severe, persistent, or accompanied by fever, vomiting, or blood in the stool.
• The standard adult dose is 10ml (10mg) three to four times daily as needed. For children aged 6 to 12 years, 5ml (5mg) three times daily. Children under 6 years should only use Spasler-P under explicit medical supervision.
• The dose should not be exceeded without consulting a doctor. Treatment should be stopped and a doctor consulted if symptoms do not improve within 2 to 3 days.

Drug Interactions

Hyoscine Butylbromide has a limited interaction profile due to its peripheral-selective action. However, the following interactions should be noted:

• Other anticholinergic medicines including antihistamines, tricyclic antidepressants, antipsychotics, and atropine: Additive anticholinergic effects increase the risk of dry mouth, urinary retention, constipation, and confusion, particularly in elderly patients.
• Dopaminergic medicines such as metoclopramide: Spasler-P may reduce the prokinetic effect of metoclopramide on gut motility, as their mechanisms oppose each other.
• Amantadine and quinidine: These medicines have anticholinergic properties that can add to the effects of Hyoscine Butylbromide.
• Beta-blockers: Hyoscine Butylbromide can enhance the heart rate-increasing effect of this interaction to a minor degree.

Risks and warnings

• Masking serious pathology: Spasler-P relieves spasmodic pain but does not treat its cause. Persistent, severe, or worsening abdominal pain must always be investigated by a doctor to rule out surgical emergencies such as appendicitis, bowel obstruction, or perforation.
• Glaucoma: Anticholinergic medicines including Hyoscine Butylbromide can raise intraocular pressure. Spasler-P is contraindicated in patients with narrow-angle glaucoma.
• Prostatic hypertrophy: Anticholinergic effects can worsen urinary flow problems in men with an enlarged prostate. Spasler-P should be used with caution in this group.
• Ulcerative colitis: Spasler-P must be used with caution in patients with ulcerative colitis. Reducing gut motility can precipitate toxic megacolon, a life-threatening complication.
• Cardiac conditions: Hyoscine Butylbromide can cause tachycardia. It should be used with caution in patients with heart disease, arrhythmias, or cardiac insufficiency.
• Elderly patients: Older adults are more sensitive to anticholinergic effects including dry mouth, constipation, urinary retention, and confusion.
• Pregnancy: Spasler-P should only be used during pregnancy when a doctor determines the benefit clearly outweighs any risk. Safety in pregnancy has not been fully established.
• Breastfeeding: It is not known whether Hyoscine Butylbromide passes into breast milk in significant amounts. A doctor should be consulted before use during breastfeeding.
• Children under 6 years: Spasler-P should not be given to children under 6 years of age without explicit medical supervision.
• Driving and machinery: Although Spasler-P does not cause significant sedation, blurred vision and dizziness can occur at higher doses. Caution is advised when driving or operating heavy machinery.

Spasler-P Syrup Side Effects

Most patients tolerate Spasler-P well at recommended doses. Side effects are related to its anticholinergic properties and are generally mild.

• Dry mouth.
• Blurred vision or difficulty focusing.
• Mild urinary hesitancy, particularly in older male patients.
• Increased heart rate (tachycardia) at higher doses.
• Skin flushing.
• Nausea or mild stomach discomfort.

Serious side effects are rare. Medical attention should be sought immediately if any of the following occur:

• Severe allergic reaction including facial swelling, difficulty breathing, or widespread rash.
• Severe urinary retention or inability to urinate.
• Rapid or irregular heartbeat that is persistent or distressing.
• Worsening abdominal pain or signs of bowel obstruction including absence of bowel movements and severe bloating.

Storage Conditions

• Store at room temperature, between 15°C and 30°C.
• Keep away from direct sunlight, heat, and moisture.
• Always keep the bottle tightly capped after use.
• Keep out of reach and sight of children.
• Do not use after the expiry date printed on the bottle.
• Do not store in the bathroom or near a kitchen sink.