Synalgo Tablet 100mg

About Synalgo Tablet 100mg

Synalgo Tablet Uses

• Relief of mild to moderate pain and inflammation in osteoarthritis and rheumatoid arthritis.
• Management of musculoskeletal pain including sprains, strains, and muscle injuries.
• Treatment of dental pain and postoperative pain following dental procedures.
• Relief of dysmenorrhea and menstrual cramps.
• Management of migraine headaches and other types of pain conditions.

Synalgo Tablet Benefits

• Rapid onset of pain relief within 30 to 60 minutes of administration.
• Potent anti-inflammatory effect reduces swelling and stiffness.
• Improved mobility and functional ability in arthritic conditions.
• Long duration of action enables convenient twice to three times daily dosing.
• Effective pain relief comparable to other NSAIDs.

What Experts Say

Flurbiprofen is a profenic acid NSAID that selectively inhibits cyclooxygenase enzymes responsible for prostaglandin synthesis. The drug blocks both COX-1 and COX-2 enzymes with preferential inhibition of COX-1 at therapeutic doses. This inhibition reduces prostaglandin E2 and prostacyclin production preventing vasodilation, increased vascular permeability, and pain sensitization. Flurbiprofen demonstrates potent analgesic and anti-inflammatory effects through multiple mechanisms including reduced inflammatory mediator release and decreased pain receptor activation.

Pharmacokinetically, flurbiprofen demonstrates rapid oral absorption with peak plasma concentrations within 1 to 2 hours. The drug is highly protein-bound at approximately 99 percent. Flurbiprofen undergoes hepatic metabolism with renal excretion of metabolites. The plasma half-life approximates 3 to 4 hours enabling twice to three times daily dosing. Food intake delays absorption but does not significantly reduce total bioavailability. Steady-state concentrations are achieved within 3 to 4 days of consistent dosing.

Clinical efficacy studies demonstrate flurbiprofen effectively reduces pain and inflammation in arthritis comparable to ibuprofen and naproxen. The drug provides superior analgesia in dental pain and postoperative pain conditions. Flurbiprofen shows efficacy in dysmenorrhea management reducing menstrual pain intensity. Long-term use studies support tolerability with appropriate precautions. Patient satisfaction remains high due to rapid pain relief and improved functional capacity.

Drug Class

• Nonsteroidal Anti-inflammatory Drug, Propionic Acid Derivative

Packaging and Quantity

• Blister strip containing 10 or 20 film-coated tablets of 100 mg each.

When Not to Use Synalgo

• Known hypersensitivity to flurbiprofen or other NSAIDs.
• Active peptic ulcer disease or history of gastrointestinal bleeding.
• Severe hepatic or renal impairment.
• Uncontrolled hypertension or severe heart failure.
• Third trimester of pregnancy.

Synalgo Tablet 100mg formula

• Flurbiprofen

Available forms

• Tablets

How to use Synalgo Tablet 100mg?

• Take orally with a full glass of water after meals to minimize gastrointestinal upset.
• Typical adult dose for pain and inflammation is 100 to 200 mg daily in divided doses.
• For arthritis: 200 to 300 mg daily in divided doses is commonly prescribed.
• For acute pain: one 100 mg tablet every 6 to 8 hours as needed.
• Do not exceed 300 mg per day without medical guidance.

Drug Interactions

Synalgo may interact with various medications affecting efficacy or safety:

• Anticoagulants: Warfarin and other anticoagulants may have increased bleeding risk; monitor INR.
• Antihypertensive agents: ACE inhibitors, ARBs, and diuretics may have reduced efficacy; monitor blood pressure.
• Lithium: Flurbiprofen may increase lithium levels; dose adjustment may be necessary.
• Methotrexate: Concurrent use may increase methotrexate toxicity; monitor carefully.
• Other NSAIDs: Concurrent use increases gastrointestinal and renal toxicity risk.

Risks and warnings

• Gastrointestinal risk: NSAIDs increase peptic ulcer and bleeding risk; use lowest effective dose for shortest duration.
• Cardiovascular effects: Long-term NSAID use may increase myocardial infarction and stroke risk.
• Renal impairment: NSAIDs reduce renal blood flow; monitor renal function in at-risk patients.
• Hepatic disease: Use with caution in liver disease; severe impairment is a contraindication.
• Pregnancy: Contraindicated in third trimester; avoid first two trimesters unless essential.
• Breastfeeding: Small amounts pass into breast milk; use with caution during lactation.
• Food intake: Always take with food or milk to reduce gastrointestinal irritation.

Synalgo Tablet Side Effects

Most side effects are mild and transient with food intake. Following are commonly reported adverse effects:

• Gastrointestinal upset, nausea, or indigestion.
• Diarrhea or constipation.
• Headache or dizziness.
• Rash or pruritus.
• Mild fluid retention.

Serious side effects requiring immediate medical attention:

• Gastrointestinal bleeding or perforation.
• Severe allergic reaction with anaphylaxis.
• Hepatotoxicity with jaundice or liver dysfunction.
• Severe renal failure or acute kidney injury.

Storage Conditions

• Store at room temperature between 15 to 25 degrees Celsius.
• Protect from moisture and direct sunlight.
• Keep in original blister packaging to maintain tablet integrity.
• Keep away from heat and humidity sources.
• Keep out of reach of children and pets.
• Do not use after the expiration date on the packaging.