Tefno Injection 500mg

About Tefno Injection 500mg

Tefno Injection 500mg Uses

• Treats severe respiratory and urinary tract infections
• Manages bacterial septicemia
• Used for bone and joint infections
• Treats meningitis and pelvic inflammatory disease

Tefno Injection 500mg Benefits

• Offers broad spectrum coverage against many bacteria
• Allows once daily dosing convenience
• Is effective for both hospital and outpatient use
• Penetrates cerebrospinal fluid well for meningitis treatment

What Experts Say

Ceftriaxone's long half-life allows once-daily dosing, which is unusual among injectable antibiotics and makes it convenient for both inpatient and outpatient intramuscular treatment. Doctors select the dose, 500 mg, 1 g, or higher, based on the severity and site of the infection being treated.

Physicians avoid mixing ceftriaxone with calcium-containing intravenous fluids, particularly in newborns, because of a documented risk of fatal precipitate formation in the lungs and kidneys. Patients with a history of severe penicillin allergy are also monitored closely, since cross-reactivity between the two antibiotic classes can occur.

Serious bacterial infections such as pneumonia, urinary sepsis, and meningitis are treated in hospitals across Pakistan with ceftriaxone as a first-line option, given its broad coverage and ease of administration. Its ability to cross into cerebrospinal fluid makes it a preferred choice when meningitis is suspected before culture results return.

Drug Class

• Third-generation cephalosporin antibiotic

Tefno Injection 500mg formula

• Ceftriaxone Sodium

Available forms

• Injection

How to use Tefno Injection 500mg?

• The injection is administered by a healthcare professional, either into a muscle or a vein.
• The dose and duration depend on the severity and site of the infection being treated.
• The reconstituted solution is used promptly, following the pharmacist's instructions.
• This medicine is not self-administered at home.

Drug Interactions

• Calcium containing intravenous solutions: Mixing these with ceftriaxone can cause dangerous precipitation, especially in infants.
• Warfarin and other blood thinners: Ceftriaxone can increase the bleeding risk with anticoagulants.
• Aminoglycoside antibiotics: These work well together but should not be mixed in the same infusion line.
• NSAIDs: Combined use can raise the risk of bleeding.

Risks and warnings

• Newborn caution: Ceftriaxone is avoided in newborns with jaundice, since it can worsen bilirubin related complications.
• Calcium interaction: It is never mixed with calcium containing intravenous fluids, particularly in infants, due to a risk of fatal precipitation.
• Penicillin allergy: Patients with a severe penicillin allergy may also react to ceftriaxone.
• Gallbladder effect: Prolonged use can cause gallbladder sludge or stone-like deposits.

Tefno Injection 500mg Side Effects

• Pain at the injection site
• Diarrhea
• Nausea
• Skin rash
• Eosinophilia
• Rare Clostridioides difficile associated diarrhea
• Rare elevated liver enzymes

Storage Conditions

• Store the unopened vial below 30°C, away from light.
• Use the reconstituted solution within the time advised by the pharmacist.
• Refrigerate the reconstituted solution if it is not used immediately.
• Keep out of reach of children.