Uperio tablet 100mg

About Uperio tablet 100mg

Uperio tablet 100mg Uses

• Chronic heart failure with reduced pumping function
• Reducing hospital admissions related to heart failure
• Lowering the risk of cardiovascular death in heart failure patients
• Long term management alongside other heart failure medicines

Drug Class

• Angiotensin receptor neprilysin inhibitor (ARNI)
• Heart failure therapy

What Experts Say

Uperio combines two actions in one tablet, sacubitril raises helpful heart hormones while valsartan relaxes blood vessels, together easing the heart's workload.

It is usually started at a low dose and increased gradually to the dose the heart tolerates best, typically taken twice daily.

It must never be combined with an ACE inhibitor, and switching between the two needs a 36 hour gap to avoid a serious swelling reaction.

Uperio tablet 100mg formula

• Sacubitril 49mg
• Valsartan 51mg

Available forms

• Tablet

How to use Uperio tablet 100mg?

• Take one tablet twice daily, morning and evening.
• Swallow with water, with or without food.
• Do not stop suddenly without consulting your doctor.
• Have blood pressure, potassium, and kidney function checked regularly.

Drug Interactions

Uperio interacts with several heart and blood pressure medicines.

• ACE inhibitors: Combining raises the risk of serious swelling, a 36 hour gap is required when switching.
• Potassium sparing diuretics or supplements: Can raise potassium to unsafe levels.
• NSAIDs: May reduce kidney function when combined.
• Lithium: Uperio can raise lithium levels, increasing toxicity risk.

Risks and warnings

• ACE inhibitor use: Never combine with an ACE inhibitor, wait at least 36 hours when switching, due to serious swelling risk.
• High potassium: Can raise blood potassium levels, needing periodic blood tests.
• Low blood pressure: May cause dizziness, especially when starting treatment.
• Kidney function: Monitor kidney function regularly during treatment.
• Pregnancy: Avoid in pregnancy, as it can cause fetal harm.

Uperio tablet 100mg Side Effects

• Low blood pressure
• Dizziness
• High potassium levels
• Cough
• Kidney function changes
• Swelling of face or throat (rare but serious)

Storage Conditions

Store below 30°C in a dry place away from moisture and direct sunlight, out of reach of children.