Xolair Injection 150mg

About Xolair Injection 150mg

Xolair Injection 150mg Uses

• Moderate to severe persistent allergic asthma not controlled by inhaled corticosteroids and a long acting bronchodilator
• Chronic spontaneous urticaria (chronic hives) that continues despite high dose antihistamines
• Chronic rhinosinusitis with nasal polyps in confirmed IgE mediated cases

Xolair Injection 150mg Benefits

• Reduces the frequency and severity of asthma flare ups
• Lowers dependence on oral corticosteroid bursts over time
• Reduces itching and wheal severity in chronic urticaria
• Given every 2 to 4 weeks by SC injection instead of a daily tablet

What Experts Say

Allergy specialists prescribe Xolair Injection 150mg only after a patient's asthma remains poorly controlled on high dose inhaled corticosteroids combined with a long acting bronchodilator. Dosing is calculated from body weight and total serum IgE level using a fixed reference chart, not a flat dose, so every patient's schedule differs.

Because Omalizumab carries a boxed warning for anaphylaxis, the first three injections are always given inside a clinic with at least two hours of observation afterward. Later doses still require thirty minutes of monitoring. Physicians treat this observation step as non negotiable, since a severe reaction can occur even after several uneventful doses.

For chronic urticaria, doctors reserve Omalizumab for patients whose itching and hives persist despite maximum dose antihistamines for several weeks. Many patients see a meaningful drop in oral steroid use once stabilized on Xolair, which specialists consider one of its most valuable long term benefits given the country's high burden of allergic skin and airway disease.

Drug Class

• Monoclonal antibody
• Anti IgE biologic
• Immunomodulator (respiratory and allergy)

Xolair Injection 150mg formula

• Omalizumab

Available forms

• Injection

How to use Xolair Injection 150mg?

• Given only by a trained healthcare provider as an SC injection, never self administered without prior clinic training
• Dose and injection frequency (every 2 or 4 weeks) are set from a weight and IgE reference chart, not a fixed amount
• First three doses are observed in clinic for at least 2 hours after injection
• Every later dose still requires 30 minutes of in clinic observation
• Not to be used for a sudden asthma attack or acute bronchospasm

Drug Interactions

• Live vaccines: Avoid during Omalizumab treatment since the immune modulating effect may reduce vaccine response
• Other immunosuppressants: Use with caution, combined effects on infection risk are not fully established
• Asthma controller medicines: No major interaction, but inhaled or oral steroids should be tapered slowly rather than stopped once Xolair takes effect

Risks and warnings

• Anaphylaxis: Boxed warning for a life threatening allergic reaction that can occur after any dose, including well after the injection is given
• Malignancy: A small increase in cancer cases was observed in clinical trials, so long term monitoring is advised
• Parasitic infection: May reduce immune response against certain worm infections, use with caution in high exposure areas
• Not for acute use: Does not relieve a sudden asthma attack or status asthmaticus
• Corticosteroid tapering: Oral or inhaled steroids should only be reduced gradually under medical supervision, never stopped abruptly once Xolair is started

Xolair Injection 150mg Side Effects

• Injection site redness, swelling, or pain
• Headache
• Joint and muscle pain
• Fatigue
• Upper respiratory tract infection symptoms
• Anaphylaxis (severe allergic reaction)
• Signs of malignancy noted during long term monitoring
• Fever in some pediatric patients

Storage Conditions

• Store refrigerated between 2 and 8 degrees Celsius
• Do not freeze the vial or prefilled syringe
• Keep in the original carton to protect from light
• Use strictly within the labeled expiry date and discard any unused portion
• Keep out of reach of children