Xostat Tablet 40mg

About Xostat Tablet 40mg

Xostat Tablet 40mg Uses

• Long term management of chronic hyperuricemia in patients with gout
• Lowering uric acid levels to prevent recurrent gout flares
• Used in patients who cannot tolerate or do not respond well to allopurinol
• Helps reduce the size of tophi (uric acid deposits) over time with continued use

Xostat Tablet 40mg Benefits

• Effectively lowers blood uric acid levels with once daily dosing
• Reduces the frequency of painful gout attacks with continued use
• Can be used in patients with mild to moderate kidney impairment with dose caution
• Alternative option for patients who do not tolerate allopurinol well

What Experts Say

Febuxostat works by selectively inhibiting xanthine oxidase, the enzyme responsible for converting purines into uric acid. By lowering uric acid production, it helps prevent the crystal formation in joints that triggers painful gout attacks over time.

Unlike allopurinol, febuxostat is metabolized mainly by the liver rather than the kidneys, which can make it a useful option for some patients with reduced kidney function, though dosing still needs careful individual assessment. It is not used to treat an acute gout flare, since starting it during an attack can worsen symptoms temporarily.

Regular monitoring of uric acid levels helps doctors confirm the target range is reached, usually below 6 mg per dL. Liver function and cardiovascular risk factors are also periodically reviewed, since febuxostat has been linked to a possible increase in cardiovascular related events in some studies.

Drug Class

• Xanthine oxidase inhibitor
• Antihyperuricemic agent

Xostat Tablet 40mg formula

• Febuxostat

Available forms

• Tablet

How to use Xostat Tablet 40mg?

• Take once daily, with or without food, at the same time each day
• Swallow the tablet whole with a glass of water
• Do not use to treat a sudden, acute gout attack
• Continue taking regularly even after uric acid levels normalize, unless the doctor advises otherwise

Drug Interactions

• Azathioprine and mercaptopurine: Should not be combined, since febuxostat can raise their levels to dangerous concentrations
• Theophylline: May increase theophylline blood levels when used together
• NSAIDs: Combined long term use may increase the risk of gastrointestinal side effects

Risks and warnings

• Cardiovascular risk: Some studies suggest a possible increase in heart related events, so use with caution in patients with existing heart disease
• Liver function: Liver enzyme monitoring is advised, since febuxostat is metabolized by the liver
• Gout flare on starting: May temporarily worsen gout symptoms when treatment begins, often needing anti inflammatory cover
• Severe kidney or liver disease: Use with caution and close monitoring in these patients

Xostat Tablet 40mg Side Effects

• Nausea
• Joint pain
• Diarrhea
• Headache
• Liver enzyme changes
• Rash
• Increased gout flares when starting treatment
• Dizziness

Storage Conditions

• Store below 30°C in a cool, dry place
• Keep the tablets in their original blister pack until use
• Protect from moisture and direct sunlight
• Keep out of reach of children