Zyloric Tablet 100mg

About Zyloric Tablet 100mg

Zyloric Tablet Uses

• Treatment and prevention of gout attacks caused by uric acid crystal deposition.
• Reduction of high uric acid levels in blood when production is excessive.
• Prevention of uric acid kidney stones and nephropathy.
• Management of hyperuricemia in patients receiving cancer chemotherapy.

Zyloric Tablet Benefits

• Reduces uric acid production preventing crystal formation in joints.
• Prevents painful gout attacks and joint inflammation.
• Decreases risk of chronic kidney disease and stone formation.
• Long-term management reducing uric acid-related complications.
• Improves mobility and quality of life by preventing acute gout episodes.

What Experts Say

Allopurinol is a xanthine oxidase inhibitor that blocks the conversion of hypoxanthine and xanthine to uric acid. By inhibiting this enzyme, allopurinol reduces both serum and urinary uric acid levels. The mechanism prevents the formation of uric acid crystals that accumulate in joints and tissues causing the inflammatory response characteristic of gout.

Allopurinol is rapidly absorbed from the gastrointestinal tract with peak plasma concentrations within 1 to 1.5 hours. The drug undergoes hepatic metabolism producing alloxanthine, which is a more potent xanthine oxidase inhibitor with a much longer half-life of 15 to 30 hours. This extended half-life permits once-daily dosing. Uric acid levels begin decreasing within 24 to 48 hours and reach steady-state reduction within 1 to 2 weeks.

Clinical efficacy is well established for prevention of acute gout attacks and long-term uric acid management. The drug effectively lowers serum uric acid concentrations by 50 to 90% depending on dosage. Gout flare-ups may paradoxically occur during initial therapy as existing uric acid deposits mobilize; concurrent colchicine or NSAIDs provide symptomatic relief during this period.

Drug Class

• Xanthine Oxidase Inhibitor

Packaging and Quantity

• Strip containing 10 tablets or blister pack containing 50 tablets.

When Not to Use Zyloric

• Known hypersensitivity to allopurinol or any component.
• Acute gout attack or acute gouty arthritis.
• Asymptomatic hyperuricemia without history of gout.
• Pre-existing skin conditions including psoriasis or eczema.

Zyloric Tablet 100mg formula

• Allopurinol

Available forms

• Tablets
• Injection

How to use Zyloric Tablet 100mg?

• Take orally once daily after meals with plenty of water.
• Swallow tablet whole without crushing or chewing.
• Typical starting dose is 100mg daily increasing based on serum uric acid levels.
• Do not stop abruptly as this may trigger acute gout episodes.
• Monitor uric acid levels regularly with blood tests.
• Take 100mg once daily or as prescribed by your doctor.

Drug Interactions

Allopurinol interacts with several medications affecting uric acid metabolism:

• Azathioprine and 6-mercaptopurine: Allopurinol increases toxicity of these drugs; dose reduction required.
• Warfarin: May increase anticoagulant effect; monitoring of INR advised.
• Thiazide diuretics: May reduce allopurinol efficacy; additive hyperuricemia risk.
• Cyclosporine: May increase cyclosporine levels; monitor renal function and levels.
• ACE inhibitors: Increased allergic reaction risk when combined with allopurinol.

Risks and warnings

• Acute gout flare: May occur during initial therapy; use prophylaxis with colchicine or NSAIDs for first 3-6 months.
• Severe rash and hypersensitivity: Discontinue immediately if rash develops; risk of Stevens-Johnson syndrome.
• Renal impairment: Dose adjustment essential in kidney disease; contraindicated in severe renal failure.
• Hepatic impairment: Use with caution in liver disease; monitor liver function tests regularly.
• Do not stop abruptly: Sudden discontinuation may trigger severe gout attacks; gradual dose reduction if needed.
• Pregnancy and breastfeeding: Use only if benefits outweigh risks; allopurinol passes into breast milk.

Zyloric Tablet Side Effects

Most patients tolerate this medication well with minimal side effects.

• Nausea or gastrointestinal upset.
• Headache or dizziness.
• Mild skin rash or pruritus.
• Acute gout flare during initial treatment.

Serious side effects are uncommon but require immediate medical attention:

• Severe skin rash including Stevens-Johnson syndrome or toxic epidermal necrolysis.
• Hepatotoxicity or liver injury with jaundice.
• Bone marrow suppression with anemia or thrombocytopenia.
• Severe hypersensitivity syndrome with fever and lymphadenopathy.

Storage Conditions

• Store at room temperature between 15-30°C.
• Keep away from direct sunlight and excessive heat.
• Protect from moisture in a tightly sealed container.
• Keep in original blister strip or tablet container.
• Keep out of reach of children and pets.
• Do not use after the expiration date on the packaging.