Orchitis treatment is carried out by certified Urologists and can include antibiotics or anti-inflammatory drugs depending on what's causing the problem. Orchitis is a condition that leads to inflammation in one or both testicles. Patients may experience symptoms such as enlarged testicles, testicular pain, fever, and nausea. Orchitis usually occurs due to a bacterial infection such as a sexually transmitted infection (STI). In some cases, it may be due to a viral infection.