Abriva Plus Tablet 400 / 100 mg

About Abriva Plus Tablet 400 / 100 mg

Abriva Plus Tablet 400 / 100 mg Uses

• Chronic hepatitis C virus (HCV) infection, genotypes 1 through 6
• Hepatitis C with or without compensated cirrhosis
• Hepatitis C in patients with decompensated cirrhosis, combined with ribavirin

Abriva Plus Tablet 400 / 100 mg Benefits

• Achieves high sustained virologic response (viral cure) rates
• Pangenotypic coverage removes the need for genotype testing before treatment
• Once daily oral dosing simplifies a full course of hepatitis C therapy

What Experts Say

Sofosbuvir is a nucleotide analog that gets converted inside liver cells into its active triphosphate form, which blocks the hepatitis C virus NS5B RNA polymerase. This enzyme is essential for the virus to copy its genetic material, so blocking it halts viral replication.

Velpatasvir works differently, targeting the NS5A protein that the hepatitis C virus needs to assemble new viral particles and pass them between liver cells. Combining an NS5B inhibitor with an NS5A inhibitor attacks the virus at two separate steps, which raises cure rates and lowers the chance of drug resistance developing.

This fixed dose combination is taken as a single tablet once daily for 12 weeks in most genotype 1 through 6 infections, with treatment extended to 24 weeks when ribavirin is added for decompensated cirrhosis. Regular liver function monitoring during treatment helps track response and catch any early signs of liver related side effects.

Drug Class

• NS5B Polymerase Inhibitor (Sofosbuvir)
• NS5A Inhibitor (Velpatasvir)
• Direct Acting Antiviral (DAA) Combination

Abriva Plus Tablet 400 / 100 mg formula

• Sofosbuvir + Velpatasvir

Available forms

• Tablet

How to use Abriva Plus Tablet 400 / 100 mg?

• Take one tablet by mouth once daily, with or without food
• Swallow the tablet whole, do not crush or split it
• Complete the full prescribed course, usually 12 weeks, even if you feel better
• Take at the same time every day to maintain steady drug levels

Drug Interactions

• Amiodarone: Combined use can cause severe, sometimes fatal, slow heart rate
• Rifampin: Reduces sofosbuvir and velpatasvir levels significantly, avoid combining
• Proton Pump Inhibitors: Reduce velpatasvir absorption, dose timing and acid suppression limits apply
• St John's Wort: Lowers drug levels enough to risk treatment failure
• Statins: Velpatasvir can raise statin levels, increasing the risk of muscle related side effects

Risks and warnings

• Hepatitis B Reactivation: Screen for hepatitis B before starting, as reactivation has occurred during direct acting antiviral treatment
• Bradycardia Risk: Serious slow heart rate can occur when combined with amiodarone, avoid this combination
• Pregnancy: Avoid use with ribavirin during pregnancy due to significant birth defect risk
• Liver Decompensation: Use only under specialist supervision in patients with decompensated cirrhosis
• Kidney Function: Use with caution in patients with severe kidney impairment

Abriva Plus Tablet 400 / 100 mg Side Effects

• Headache
• Fatigue
• Nausea
• Diarrhea
• Insomnia
• Irritability
• Decreased appetite
• Joint pain
• Dizziness
• Anemia (when combined with ribavirin)

Storage Conditions

• Store below 30°C in a cool, dry place
• Keep the tablets in their original packaging until use
• Protect from moisture and direct sunlight
• Keep out of reach of children