Sofvel Tablet 400mg / 100mg

About Sofvel Tablet 400mg / 100mg

Sofvel Tablet 400mg / 100mg Uses

• Treatment of chronic Hepatitis C virus infection in adults
• Used across multiple Hepatitis C genotypes without needing separate genotype testing in most cases
• Prescribed for patients with or without compensated cirrhosis, as advised by a specialist
• Part of a full course therapy typically lasting twelve weeks

Sofvel Tablet 400mg / 100mg Benefits

• Achieves high cure rates for chronic Hepatitis C in most patients
• Covers several Hepatitis C genotypes with one combination tablet
• Once daily oral dosing makes the treatment course easier to follow
• Generally shorter treatment duration compared to older Hepatitis C regimens

What Experts Say

Sofosbuvir is a nucleotide analogue that blocks the NS5B polymerase enzyme the Hepatitis C virus needs to copy its genetic material, while velpatasvir blocks the NS5A protein involved in viral assembly and replication. Together they attack the virus at two different stages of its life cycle.

This dual mechanism is why the combination works across genotypes without requiring separate genotype specific regimens in most patients, which has simplified Hepatitis C treatment considerably compared to older interferon based therapies that carried much heavier side effects.

Doctors confirm the diagnosis and genotype where relevant, check liver function and kidney function before starting, and monitor viral load during and after the twelve week course to confirm a sustained response. Medication adherence for the full course is considered essential for achieving a lasting cure, since missed doses can allow the virus to develop resistance to therapy.

Drug Class

• Direct acting antiviral
• NS5B polymerase inhibitor plus NS5A inhibitor combination

Sofvel Tablet 400mg / 100mg formula

• Sofosbuvir + Velpatasvir

Available forms

• Tablet

How to use Sofvel Tablet 400mg / 100mg?

• Take one Sofvel Tablet by mouth once daily, with or without food
• Take it at the same time each day for the full prescribed course
• Do not stop the course early even if you feel better
• If you miss a dose within eighteen hours of the usual time, take it as soon as you remember
• Attend all follow up visits for blood tests during treatment

Drug Interactions

Sofvel Tablet can interact with several other medicines, so tell your doctor about everything you take.

• Amiodarone: Combined use can cause dangerously slow heart rates, generally avoided
• Acid reducing medicines (antacids, H2 blockers, proton pump inhibitors): Can lower absorption of velpatasvir if timing is not spaced correctly
• Certain anticonvulsants such as carbamazepine or phenytoin: May reduce Sofvel's effectiveness
• Rifampin and similar drugs: Can significantly lower blood levels of both active ingredients

Risks and warnings

• Hepatitis B reactivation: Can occur in patients also infected with Hepatitis B, needs screening before starting
• Pregnancy: Use only if clearly needed and under specialist guidance
• Kidney impairment: May require dose review in patients with significant kidney disease
• Amiodarone use: Combining with this heart medicine has caused dangerously slow heart rates
• Liver monitoring: Regular liver function tests are advised throughout treatment

Sofvel Tablet 400mg / 100mg Side Effects

Sofvel Tablet is generally well tolerated, but some mild effects can occur.

• Headache
• Fatigue
• Nausea
• Trouble sleeping
• Diarrhea

Contact your doctor or seek medical help right away if you notice these serious effects.

• Very slow heartbeat, especially if also taking amiodarone
• Signs of Hepatitis B reactivation such as yellowing of the skin or eyes
• Severe fatigue or confusion
• Signs of an allergic reaction such as rash or swelling

Storage Conditions

• Store below 30°C in a cool, dry place away from sunlight
• Keep the tablets in their original blister pack until the dose is due
• Keep out of reach of children
• Do not use after the expiry date printed on the pack