Hilvel Tablet 400mg / 100mg

About Hilvel Tablet 400mg / 100mg

Hilvel Tablet 400mg / 100mg Uses

• Treatment of chronic hepatitis C virus infection in adults
• Used across multiple hepatitis C genotypes, including genotype 3 common in Pakistan
• Prescribed with or without cirrhosis, based on doctor assessment
• Part of a fixed twelve week oral treatment course in most cases

Hilvel Tablet 400mg / 100mg Benefits

• Clears hepatitis C virus from the blood in most patients within one course
• Once daily dosing improves treatment adherence
• Avoids the need for injectable interferon therapy used in older regimens
• Reduces long term risk of liver cirrhosis and liver cancer linked to untreated hepatitis C

What Experts Say

Sofosbuvir blocks the NS5B polymerase enzyme that the hepatitis C virus needs to copy its genetic material. Velpatasvir works differently by targeting the NS5A protein, which the virus uses to assemble new copies inside liver cells. Combining both drugs attacks the virus at two separate steps in its life cycle.

Clinical trials across multiple hepatitis C genotypes show this combination clears the virus from the blood in most patients after twelve weeks of daily use. Doctors in Pakistan often prefer this pairing because it works against genotype 3, which is the most common strain seen locally and historically harder to treat with older regimens.

Regular liver function monitoring and a baseline viral load test are usually recommended before starting therapy. Patients with cirrhosis or prior treatment failure may need a longer course or an additional antiviral, so a hepatologist should confirm the exact regimen and duration.

Drug Class

• Direct acting antiviral (DAA)
• NS5B polymerase inhibitor (Sofosbuvir)
• NS5A inhibitor (Velpatasvir)

Hilvel Tablet 400mg / 100mg formula

• Sofosbuvir + Velpatasvir

Available forms

• Tablet

How to use Hilvel Tablet 400mg / 100mg?

• Take one tablet by mouth once daily, with or without food, at roughly the same time each day
• Swallow the tablet whole, do not crush or split it
• Complete the full twelve week course even if symptoms are not noticeable
• Do not skip doses, missing tablets can lower the chance of clearing the virus
• Avoid acid reducing medicines like antacids, H2 blockers and proton pump inhibitors close to dosing unless the doctor allows a specific timing gap

Drug Interactions

• Amiodarone: Can cause severe symptomatic bradycardia, this combination should be avoided
• Rifampin and carbamazepine: Strong enzyme inducers that lower drug levels and reduce effectiveness
• Proton pump inhibitors and antacids: Reduce absorption of Velpatasvir, timing must be separated or avoided
• Rosuvastatin: Blood levels can rise, dose adjustment may be needed
• St. John's Wort: Reduces effectiveness of the combination and should not be taken together

Risks and warnings

• Bradycardia risk: Serious slow heart rate has occurred when taken with amiodarone, this combination should be avoided
• Liver disease: Patients with decompensated cirrhosis need close specialist monitoring during treatment
• Kidney function: Dose adjustment or caution needed in patients with significant kidney impairment
• Pregnancy: Safety in pregnancy is not established, discuss contraception with the doctor before starting
• Hepatitis B reactivation: Patients with prior hepatitis B infection should be screened before starting therapy

Hilvel Tablet 400mg / 100mg Side Effects

• Headache
• Fatigue
• Nausea
• Diarrhea
• Insomnia
• Irritability
• Dizziness
• Slow heart rate when combined with amiodarone, seek urgent care if this occurs

Storage Conditions

• Store at room temperature, below 30 degrees Celsius
• Keep the tablets in their original blister pack until use
• Protect from direct sunlight and moisture
• Keep out of reach of children