Acifre Capsule 20mg

About Acifre Capsule 20mg

Acifre Capsule 20mg Uses

• Treats gastroesophageal reflux disease (GERD)
• Heals and prevents stomach and duodenal ulcers
• Used alongside antibiotics to treat H. pylori infection
• Reduces acid related damage from long term NSAID or aspirin use

Acifre Capsule 20mg Benefits

• Provides longer lasting acid suppression than older acid reducing medicines
• Eases heartburn, chest discomfort and acid regurgitation
• Supports healing of the esophagus lining damaged by reflux
• Once daily dosing improves treatment convenience

What Experts Say

Esomeprazole is the S-isomer of omeprazole and belongs to the proton pump inhibitor class. It binds irreversibly to the proton pump on stomach lining cells, which blocks the final step of acid production at its source rather than simply neutralizing acid that is already present in the stomach at the time of dosing.

Because esomeprazole undergoes less variable liver metabolism than the standard omeprazole mixture, pharmacology studies show it can achieve more consistent and slightly stronger acid suppression across different patients at an equivalent dose, with noticeably fewer differences based on each patient's individual liver enzyme activity levels.

Since proton pump inhibitors need newly made pumps to act on, experts advise taking this capsule on an empty stomach before a meal, when stomach cells are most active in producing new acid pumps for the drug to block during the day's digestive process.

Drug Class

• Proton pump inhibitor (PPI)
• Antisecretory agent

Acifre Capsule 20mg formula

Available forms

• Capsule

How to use Acifre Capsule 20mg?

• Take Acifre Capsule 20mg once daily, usually in the morning
• Swallow the capsule whole, 30 to 60 minutes before a meal
• Do not crush, chew or open the capsule
• Take at the same time each day for best results
• Complete the full course even if symptoms improve early

Drug Interactions

• Clopidogrel: Esomeprazole can reduce the blood thinning effect of clopidogrel
• Methotrexate: May raise methotrexate levels when used together at high doses
• Antifungal Drugs (Ketoconazole): Reduced stomach acid can lower their absorption
• Diazepam: Esomeprazole may slow the breakdown of diazepam, raising its blood levels

Risks and warnings

• Long Term Use: Extended use may lower magnesium and vitamin B12 levels over time
• Bone Health: Long term high dose use is linked to a small increase in fracture risk
• Kidney Function: Rare cases of kidney inflammation have been reported with prolonged use
• Masking Symptoms: May hide symptoms of a more serious stomach condition, so persistent symptoms need medical review
• Pregnancy: Use only if clearly advised by your doctor

Acifre Capsule 20mg Side Effects

• Headache
• Nausea
• Diarrhea
• Abdominal pain
• Flatulence
• Constipation
• Dry mouth
• Dizziness

Storage Conditions

• Store below 25°C in a cool, dry place away from moisture
• Keep the capsule strip sealed until use
• Keep out of reach of children
• Do not use after the expiry date printed on the pack