Amaryl M SR Tablet 1mg / 500mg

About Amaryl M SR Tablet 1mg / 500mg

Amaryl M SR Tablet Uses

• Type 2 diabetes mellitus not controlled by diet and exercise alone
• Blood sugar control when a single diabetes medicine is not enough
• Long term management of chronic hyperglycemia

Amaryl M SR Tablet Benefits

• Combines two complementary mechanisms in one tablet
• Sustained release metformin reduces stomach related side effects
• Simplifies treatment by reducing the number of tablets needed
• Supports steady blood sugar control throughout the day

What Experts Say

Glimepiride stimulates the pancreas to release more insulin, while metformin reduces glucose production by the liver and improves how the body's tissues respond to insulin. Combining both mechanisms in one tablet often achieves better blood sugar control than either drug used alone, especially as diabetes progresses over time.

Endocrinologists and general physicians frequently prescribe this type of fixed dose combination when metformin alone has stopped achieving target blood sugar levels, since adding a sulfonylurea like glimepiride can restore adequate control without needing insulin injections at that stage of treatment.

The sustained release metformin component is designed to release the drug gradually through the day, which generally causes fewer digestive complaints than immediate release metformin. Doctors still advise regular monitoring of kidney function and vitamin B12 levels during long term use of this combination.

Drug Class

• Sulfonylurea combined with a biguanide (oral antidiabetic combination)

Amaryl M SR Tablet 1mg / 500mg formula

• Glimepiride + Metformin Hydrochloride

Available forms

• Tablet

How to use Amaryl M SR Tablet 1mg / 500mg?

• Take this tablet with the first main meal of the day.
• Swallow the tablet whole without crushing or chewing, since it is a sustained release formulation.
• Take at the same time each day for steady blood sugar control.
• Do not skip meals after taking this medicine.

Drug Interactions

• Alcohol: Increases the risk of low blood sugar and lactic acidosis.
• Contrast Dye: Metformin may need to be paused around imaging procedures using iodinated contrast.
• Beta Blockers: Can mask the warning symptoms of low blood sugar.
• Corticosteroids: May raise blood sugar and reduce the medicine's effectiveness.

Risks and warnings

• Hypoglycemia: Can cause low blood sugar, especially if meals are skipped or delayed.
• Lactic Acidosis: Rare but serious risk with metformin, higher in patients with kidney or liver impairment.
• Kidney Function: Regular kidney function monitoring is recommended during treatment.
• Alcohol: Avoid excessive alcohol intake, as it raises the risk of low blood sugar and lactic acidosis.

Amaryl M SR Tablet Side Effects

• Low blood sugar (hypoglycemia)
• Nausea
• Diarrhea
• Stomach discomfort
• Metallic taste
• Loss of appetite
• Weight gain
• Lactic acidosis with symptoms like severe weakness and rapid breathing (rare)

Storage Conditions

• Store below 25°C in a dry place.
• Keep the tablet strip in its original packaging.
• Protect from moisture and direct sunlight.
• Keep out of reach of children.