About Aminophylline Injection 250 mg
Aminophylline Injection 250 mg contains Aminophylline, an IV bronchodilator for severe asthma and COPD attacks.
Aminophylline Injection 250 mg Uses
- Treats acute severe asthma attacks not responding to inhaled bronchodilators
- Manages acute exacerbations of chronic obstructive pulmonary disease (COPD)
- Used in hospital emergency treatment of status asthmaticus
- Provides rapid bronchodilation during severe bronchospasm episodes
Aminophylline Injection 250 mg Benefits
- Delivers fast acting relief for life threatening breathing difficulty
- Allows precise dose control under direct clinical supervision
- Complements other emergency asthma and COPD medicines in hospital settings
- Can be adjusted quickly based on the patient's response and blood levels
What Experts Say
Intravenous aminophylline delivers a methylxanthine bronchodilator directly into circulation, relaxing bronchial smooth muscle within minutes by inhibiting phosphodiesterase and blocking adenosine receptors. This rapid onset is useful when inhaled bronchodilators cannot act fast enough during a severe asthma or COPD attack.
The same 10 to 20 microgram per milliliter therapeutic range applies here, but the intravenous route removes the buffering effect of gut absorption, so blood levels can rise quickly during infusion. A rapid push of the drug is dangerous, since it can spike serum levels above the safe range within seconds and trigger arrhythmias or seizures.
Because clearance depends on liver enzyme activity that varies with age, smoking status, heart failure, and other medicines, hospital teams calculate a loading dose by body weight, then check serum theophylline levels before continuing maintenance infusion. This monitoring step allows the injection to be used safely despite its narrow margin between an effective and a toxic dose.
Drug Class
- Methylxanthine Bronchodilator
Aminophylline Injection 250 mg Uses in Urdu
- دمہ کے شدید دورے میں فوری سانس کھولنے کے لیے
- سی او پی ڈی کی شدید حالت میں ہسپتال میں علاج کے لیے
- سانس کی نالیوں کی شدید تنگی کو فوری کم کرنے کے لیے
- ہنگامی حالت میں دیگر ادویات کے ساتھ سانس بہتر بنانے کے لیے
Aminophylline Injection 250 mg formula
How to use Aminophylline Injection 250 mg?
- Administered only by a doctor or trained healthcare provider in a hospital setting
- Given as a slow intravenous infusion, never as a rapid injection
- Diluted in an appropriate intravenous fluid before administration
- Requires continuous heart rate and rhythm monitoring during infusion
- Dose is calculated by body weight and adjusted using serum theophylline level results
- Not intended for self administration or home use
Drug Interactions
- Ciprofloxacin: Raises aminophylline blood levels and increases the risk of toxicity during infusion.
- Erythromycin: Slows aminophylline clearance, raising the risk of high blood levels.
- Cimetidine: Reduces aminophylline metabolism and increases toxicity risk.
- Rifampin: Speeds up aminophylline breakdown, which can reduce its effect.
- Phenytoin: Lowers aminophylline blood levels through enzyme induction.
- Smoking: Increases aminophylline clearance, often requiring dose adjustment.
- Caffeine: Adds to stimulant and cardiac effects, increasing the chance of palpitations.
Risks and warnings
- Narrow Therapeutic Index: Even a small dose increase above the target range can cause serious toxicity, so serum level monitoring is essential.
- Rapid Infusion Risk: Giving the injection too quickly can cause dangerous heart rhythm changes and seizures.
- Cardiac Arrhythmias: Use with extreme caution in patients with existing heart rhythm problems.
- Seizure Risk: High blood levels can trigger seizures, especially in patients with a prior seizure history.
- Liver Impairment: Reduced liver function slows clearance and raises toxicity risk, requiring lower doses.
- Elderly Patients: Clearance is often reduced with age, increasing the risk of accumulation and toxicity.
- Hospital Only Use: Reserved for acute, severe cases under continuous clinical monitoring, not for routine outpatient use.
Aminophylline Injection 250 mg Side Effects
- Nausea and vomiting
- Fast or irregular heartbeat
- Palpitations
- Headache
- Restlessness and agitation
- Low blood pressure with rapid infusion
- Tremors
- Flushing at the injection site
- Seizures at toxic blood levels
- Cardiac arrest in severe overdose
Storage Conditions
- Store ampoules at room temperature, below 30 degrees Celsius
- Protect ampoules from light and keep in the outer carton until use
- Do not freeze the injection solution
- Inspect the solution for discoloration or particles before use
- Discard any unused portion after opening, do not reuse an opened ampoule
- Keep in hospital pharmacy controlled storage, out of reach of children
