Amizole Tablet 250mg / 200mg

About Amizole Tablet 250mg / 200mg

Amizole Tablet Uses

• Intestinal amoebiasis caused by Entamoeba histolytica
• Treatment in asymptomatic carriers of amoebic cysts
• Mixed protozoal and bacterial intestinal infections

Amizole Tablet Benefits

• Combines a cyst-clearing agent with an active-infection treatment
• Reduces the risk of relapse by targeting both cyst and active amoeba forms
• Widely used first-line option for intestinal amoebiasis in Pakistan

What Experts Say

This combination pairs diloxanide furoate, which acts mainly in the intestinal lumen to clear amoebic cysts, with metronidazole, which targets actively invading amoeba in the tissue. Together they address both the cyst-carrying and actively symptomatic stages of intestinal amoebiasis in one course of treatment.

Doctors typically prescribe this dual approach for confirmed intestinal amoebiasis to reduce the chance of relapse, since treating only the active infection with metronidazole alone can leave behind cysts capable of causing symptoms again weeks or months later. It is also considered in mixed protozoal and bacterial gut infections.

Because metronidazole can cause a significant reaction when combined with alcohol, patients are usually advised to avoid alcoholic drinks throughout treatment and for a couple of days after finishing the course. Doctors also monitor for gastrointestinal side effects during longer courses of therapy.

Drug Class

• Antiamoebic / Antiprotozoal Combination

Amizole Tablet 250mg / 200mg formula

• Diloxanide Furoate + Metronidazole

Available forms

• Tablet

How to use Amizole Tablet 250mg / 200mg?

• Take after meals to reduce stomach upset.
• Swallow the tablet whole with water.
• Take the full course as prescribed, usually for 10 days.
• Avoid alcohol throughout treatment.
• Do not double the dose if a dose is missed.

Drug Interactions

• Alcohol: Causes severe nausea, flushing, and vomiting.
• Warfarin: Metronidazole may enhance the blood-thinning effect.
• Lithium: Increases lithium levels and toxicity risk.
• Disulfiram: Risk of a psychotic reaction when combined with metronidazole.

Risks and warnings

• Alcohol Reaction: Avoid alcohol during treatment and for at least 48 hours after, due to a disulfiram-like reaction.
• Pregnancy Caution: Not recommended during the first trimester of pregnancy.
• Liver or Blood Disorders: Use with caution in liver disease or blood disorders.
• Urine Discoloration: May cause a dark or reddish-brown discoloration of urine.
• Nerve Symptoms: Report persistent numbness or tingling in the hands or feet.
• Full Course: Complete the full course even if symptoms improve early.

Amizole Tablet Side Effects

• Nausea
• Vomiting
• Metallic taste
• Abdominal cramps
• Flatulence
• Headache
• Dizziness
• Dark urine

Storage Conditions

• Store below 25°C in a dry place.
• Protect from light and moisture.
• Keep in the original packaging.
• Keep out of reach of children.