Bacticef Injection 1000mg / 1000mg

About Bacticef Injection 1000mg / 1000mg

Bacticef Injection 1000mg / 1000mg Uses

• Treatment of severe respiratory tract infections including pneumonia
• Management of complicated urinary tract infections
• Treatment of intra abdominal infections such as peritonitis
• Management of skin and soft tissue infections
• Treatment of septicemia and blood stream infections
• Management of pelvic inflammatory disease and other gynecological infections

Bacticef Injection 1000mg / 1000mg Benefits

• Covers a wide range of gram negative and gram positive bacteria
• Sulbactam protects Cefoperazone from being broken down by resistant bacteria
• Works well for infections that have not responded to simpler antibiotics
• Suitable for hospitalized patients who need fast acting IV therapy
• Reduces the risk of infection spreading to the bloodstream

What Experts Say

Cefoperazone is a third generation cephalosporin that stops bacteria from building their cell walls, which causes the bacterial cells to break apart and die. Sulbactam on its own has weak antibacterial action, but it blocks the beta lactamase enzyme that many resistant bacteria use to destroy cephalosporins.

When combined, the two drugs restore Cefoperazone's effectiveness against bacteria that would otherwise resist it, giving the injection a broader spectrum than Cefoperazone alone. This combination is commonly reserved for moderate to severe infections in hospital settings where resistant organisms are a concern.

Experts advise that the drug is given only through intravenous or intramuscular routes under medical supervision, since oral absorption is negligible. Kidney and liver function are usually checked before extended courses, as both organs play a role in clearing the medicine from the body.

Drug Class

• Third generation cephalosporin antibiotic
• Beta lactamase inhibitor combination

Bacticef Injection 1000mg / 1000mg formula

• Cefoperazone + Sulbactam

Available forms

• Injection

How to use Bacticef Injection 1000mg / 1000mg?

• Bacticef injection is administered by a trained healthcare professional through an IV or IM route
• The dose and frequency depend on the severity of infection and the patient's body weight
• Treatment usually continues for five to fourteen days as advised by the treating doctor
• The injection site should be rotated to reduce local irritation
• Renal function is usually monitored during longer courses of treatment

Drug Interactions

• Alcohol: A disulfiram like reaction with flushing, headache and nausea can occur, so alcohol should be avoided during and for several days after treatment.
• Warfarin and other anticoagulants: The bleeding risk increases when these are combined with Bacticef.
• Aminoglycosides: Combined use is common for severe infections, but kidney function needs closer monitoring.
• Probenecid: This medicine can raise Cefoperazone levels in the blood by slowing its clearance.

Risks and warnings

• Allergy Risk: Patients allergic to penicillin or other cephalosporins may also react to this injection.
• Liver Disease: Cefoperazone is cleared mainly through bile, so dose adjustment is needed in liver impairment.
• Bleeding Risk: The medicine can lower vitamin K levels, which may increase bleeding tendency in some patients.
• Alcohol Interaction: A disulfiram like reaction with flushing and nausea can occur if alcohol is consumed during treatment.
• Superinfection: Extended use can allow resistant bacteria or fungi to overgrow in the gut.

Bacticef Injection 1000mg / 1000mg Side Effects

• Pain or swelling at the injection site
• Diarrhea
• Nausea and vomiting
• Skin rash
• Fever
• Low platelet count in rare cases
• Elevated liver enzymes
• Vein inflammation with IV use

Storage Conditions

• Unopened vials should be stored at room temperature, below 25°C, away from light
• Reconstituted solution should be used within the time frame advised by the manufacturer, usually within a few hours at room temperature
• Refrigeration can extend the stability of the reconstituted solution as directed on the pack insert
• The vials should be kept out of reach of children and away from moisture