Brufen Plus Tablet 200mg / 20mg

About Brufen Plus Tablet 200mg / 20mg

Brufen Plus Tablet Uses

• Relief from moderate to moderately severe pain
• Pain control after surgery or dental procedures
• Management of musculoskeletal pain such as back pain and sprains
• Relief from pain associated with menstrual cramps
• An option when simple analgesics alone are not enough

Brufen Plus Tablet Benefits

• A dual action combination of an anti-inflammatory and an opioid analgesic for stronger pain relief
• Reduction of both pain and inflammation at the source
• Faster onset of relief for moderate pain compared to ibuprofen alone
• A lower opioid dose requirement through the combined analgesic effect

What Experts Say

Ibuprofen combined with codeine phosphate gives dual action against pain, an anti-inflammatory effect at the injury site alongside central opioid analgesia. Pakistani physicians typically reserve this combination for short courses of moderate pain that has not responded to ibuprofen or paracetamol alone.

Because codeine carries a dependence and respiratory depression risk, prescribers generally limit use to the shortest effective duration, often three to five days. Ibuprofen also requires caution in patients with a history of peptic ulcer disease or reduced kidney function, both common concerns in general practice.

Genetic variation in codeine metabolism means response can differ between patients, with some converting codeine to morphine more rapidly than others. Clinicians in Pakistan are advised to counsel patients on this variability and to avoid the combination in children under twelve given documented respiratory risks.

Drug Class

• NSAID and Opioid Combination Analgesic
• Nonsteroidal Anti-inflammatory Drug (NSAID)
• Opioid Analgesic

Brufen Plus Tablet 200mg / 20mg formula

• Ibuprofen + Codeine Phosphate

Available forms

• Tablet

How to use Brufen Plus Tablet 200mg / 20mg?

• One tablet is usually taken every six to eight hours as needed for pain.
• The tablet should be swallowed whole with a full glass of water.
• Taking it with food or milk helps reduce stomach irritation.
• The maximum dose advised by a doctor should never be exceeded.
• Alcohol should be avoided while taking this medicine.

Drug Interactions

• Anticoagulants: The risk of gastrointestinal bleeding increases when combined with warfarin or similar drugs.
• Other NSAIDs: The risk of stomach ulcers and kidney impairment rises with concurrent use.
• ACE Inhibitors and ARBs: Blood pressure control and kidney function may both be reduced.
• CNS Depressants: Drowsiness and respiratory depression risk increases when combined with alcohol, sedatives, or sleeping pills.
• Monoamine Oxidase Inhibitors: Serious interactions with the codeine component are possible, so this combination should be avoided.

Risks and warnings

• Gastrointestinal Risk: Stomach pain, ulcers, or bleeding are possible, especially with long term use.
• Respiratory Depression: Breathing can slow due to the codeine component, particularly at high doses or in children.
• Dependence Risk: Tolerance and dependence on the codeine component are possible with prolonged use.
• Cardiovascular Risk: Heart attack or stroke risk is higher with long term NSAID use like ibuprofen.
• Pregnancy Caution: The third trimester of pregnancy is a time to avoid this medicine due to risks to the unborn baby.

Brufen Plus Tablet Side Effects

• Nausea and vomiting
• Constipation
• Drowsiness or dizziness
• Stomach pain or heartburn
• Dry mouth
• Headache
• Skin rash
• Slowed breathing at high doses
• Gastrointestinal bleeding with prolonged use

Storage Conditions

• Store below 30°C in a dry place away from direct light.
• Keep the blister strip in its original packaging until use.
• Keep out of reach of children, as the opioid component poses overdose risk.
• Do not store in the bathroom or near a sink due to moisture exposure.