Colitran Tablet 80mg/400mg

About Colitran Tablet 80mg/400mg

Colitran Tablet Uses

• Urinary tract infections
• Acute bronchitis flare ups
• Traveler's diarrhea
• Ear infections in children
• Pneumocystis pneumonia prevention and treatment

Colitran Tablet Benefits

• Broad coverage against many common gram positive and gram negative bacteria
• Affordable option compared to newer antibiotic classes
• Available in tablet and suspension form for different age groups
• Once or twice daily dosing that supports treatment completion

What Experts Say

Colitran combines two antibiotics that block different steps of folic acid production inside bacteria. Trimethoprim and sulfamethoxazole work together so bacteria cannot make the folate they need to grow. This combined action makes the drug more effective than either ingredient alone and slows the development of resistance.

Doctors reach for this combination when an infection is likely caused by susceptible bacteria, especially in the urinary tract or respiratory system. It remains a first choice for uncomplicated urinary infections in many outpatient settings because it works quickly and costs relatively little. Physicians also use it for certain ear infections in children and for preventing specific lung infections in people with weakened immunity.

In Pakistan, this combination is widely prescribed because it is inexpensive and easy to access at almost every pharmacy. Rising antibiotic resistance in the region means doctors now check local resistance patterns before relying on it for serious infections. Patients are still advised to complete the full course even if symptoms improve within a day or two.

Drug Class

• Sulfonamide antibiotic combination
• Folate synthesis inhibitor

Colitran Tablet 80mg/400mg formula

• Trimethoprim + Sulfamethoxazole

Available forms

• Tablet

How to use Colitran Tablet 80mg/400mg?

• Take Colitran Tablet with a full glass of water.
• Swallow the tablet whole, preferably after a meal.
• Complete the full course even if symptoms improve early.
• Take doses at evenly spaced times each day.
• Drink extra water throughout the treatment period.

Drug Interactions

• Warfarin: This combination can increase the blood thinning effect and raise bleeding risk.
• Methotrexate: Combined use can increase methotrexate toxicity.
• ACE Inhibitors: Concurrent use with drugs like lisinopril can raise potassium levels.
• Phenytoin: This antibiotic can raise phenytoin levels and increase side effects.

Risks and warnings

• Allergy Risk: Sulfa allergies can trigger severe skin reactions and require immediate medical attention.
• Kidney Function: Reduced kidney function raises the risk of drug buildup and needs dose adjustment.
• Blood Disorders: Long courses can lower blood cell counts, so periodic blood tests are advised.
• Pregnancy: This combination is generally avoided in the first trimester and near delivery.
• Sun Sensitivity: Skin can become more sensitive to sunlight during treatment.

Colitran Tablet Side Effects

• Nausea and stomach upset
• Loss of appetite
• Headache
• Skin rash
• Diarrhea
• Sensitivity to sunlight
• Severe allergic reactions in rare cases
• Drop in blood cell counts with prolonged use

Storage Conditions

• Store below 25°C in a cool, dry place.
• Keep the tablets in their original packaging away from moisture.
• Keep out of reach of children.
• Discard any unused tablets after the expiry date.