Sulprim Tablet 80mg / 400mg

About Sulprim Tablet 80mg / 400mg

Sulprim Tablet 80mg / 400mg Uses

• Urinary tract infections
• Respiratory tract infections such as bronchitis
• Ear infections including otitis media
• Traveler's diarrhea and certain intestinal infections
• Prevention of pneumocystis pneumonia in people with weakened immunity, when prescribed

Sulprim Tablet 80mg / 400mg Benefits

• Combines two antibiotics that block sequential steps in bacterial folate production
• Broad activity against many common gram positive and gram negative bacteria
• Convenient twice daily oral dosing for most infections
• Cost effective option among antibacterial tablets

What Experts Say

Trimethoprim and sulfamethoxazole act on two consecutive steps of the same bacterial pathway that produces folic acid. Sulfamethoxazole blocks an earlier enzyme in this pathway while trimethoprim blocks a later one, and using them together produces a stronger antibacterial effect than either drug gives alone.

This combination covers a wide range of bacteria responsible for urinary, respiratory, ear and intestinal infections, and it also has a specific role in preventing and treating pneumocystis pneumonia in people whose immune systems are weakened. Resistance patterns vary by region, so local susceptibility data often guides whether it remains a suitable first choice for a given infection.

Sulfamethoxazole is a sulfonamide, a drug class linked to hypersensitivity reactions ranging from mild rash to rare but serious skin reactions. The combination is cleared through the kidneys, so doses are adjusted in kidney impairment, and it is generally avoided late in pregnancy and in very young infants due to a risk of newborn jaundice.

Drug Class

• Sulfonamide antibiotic combination, a folate synthesis inhibitor

Sulprim Tablet 80mg / 400mg formula

• Trimethoprim + Sulfamethoxazole

Available forms

• Tablet

How to use Sulprim Tablet 80mg / 400mg?

• Take this tablet by mouth with a full glass of water
• Take it with food if it upsets your stomach
• Space doses evenly, usually every 12 hours
• Drink extra fluids during the course unless your doctor advises otherwise
• Complete the full course even if you feel better before it ends

Drug Interactions

Sulprim Tablet 80mg / 400mg may interact with certain other drugs, so always inform your doctor of your current treatments.

• Warfarin: Increases the blood thinning effect and bleeding risk
• Methotrexate: Raises methotrexate toxicity and the risk of low blood counts
• ACE inhibitors or ARBs: Combined use can raise blood potassium to unsafe levels
• Phenytoin: Levels of phenytoin can increase, raising the risk of side effects

Risks and warnings

• Sulfa allergy: Avoid if you have a known allergy to sulfonamide medicines
• Skin reactions: Stop the medicine and seek care immediately if a rash, blistering or peeling develops
• Kidney function: Needs dose adjustment in people with reduced kidney function
• Pregnancy and infants: Avoid in late pregnancy and in infants under two months due to newborn jaundice risk
• G6PD deficiency: Use with caution, since it can trigger red blood cell breakdown in this condition

Sulprim Tablet 80mg / 400mg Side Effects

Most people tolerate Sulprim Tablet 80mg / 400mg well when it is taken correctly. Some mild effects can still occur.

• Nausea
• Vomiting
• Loss of appetite
• Skin rash
• Headache
• Photosensitivity, meaning easier sunburn

Seek medical help right away if you notice any of the following serious effects.

• Severe skin reactions such as blistering or peeling
• Yellowing of the skin or eyes suggesting liver involvement
• Unusual bruising or bleeding suggesting a blood count change

Storage Conditions

• Store below 25°C in a dry place away from sunlight
• Keep the tablets in the original strip until needed
• Keep out of reach of children
• Avoid use beyond the expiry date printed on the pack