Diagesic Tablet 32.5/325mg

About Diagesic Tablet 32.5/325mg

Diagesic Tablet Uses

• Mild to moderate pain relief
• Muscular pain and body aches
• Headache
• Toothache
• Post operative pain
• Menstrual cramps

Diagesic Tablet Benefits

• Combines a mild opioid analgesic with paracetamol for stronger combined pain control
• Can offer relief when paracetamol alone is not enough
• Convenient oral tablet dosing
• Useful for short term management of moderate pain episodes

What Experts Say

Dextropropoxyphene is a mild opioid analgesic that acts on the central nervous system to change how the brain perceives pain signals. When combined with paracetamol, which works through a different pathway to relieve pain and lower fever, the two ingredients together give a stronger combined analgesic effect than either drug used alone.

Clinical references classify this combination as suitable for short term relief of mild to moderate pain that does not respond well to paracetamol alone. Because dextropropoxyphene carries a known risk of cardiac toxicity in overdose, current prescribing practice favors using it only when safer options are inadequate and for the shortest duration needed.

Regulators in several countries have withdrawn dextropropoxyphene from routine use because of this narrow gap between an effective dose and a dangerous one. Doctors who still prescribe this combination in Pakistan generally limit it to supervised short term use and monitor patients closely, especially those with existing heart problems.

Drug Class

• Opioid Analgesic (Dextropropoxyphene)
• Non Opioid Analgesic and Antipyretic (Paracetamol)

Diagesic Tablet 32.5/325mg formula

• Dextropropoxyphene HCl 32.5mg + Paracetamol 325mg

Available forms

• Tablet

How to use Diagesic Tablet 32.5/325mg?

• Take one tablet by mouth exactly as directed by the doctor
• Swallow the tablet whole with a full glass of water
• Take with or after food to reduce stomach upset
• Do not exceed the prescribed dose or frequency
• Do not use for longer than the prescribed duration

Drug Interactions

• Alcohol: Increases sedation and raises the risk of liver and heart toxicity.
• Other Opioid Analgesics: Combined use raises the risk of excessive sedation and breathing difficulty.
• Sedatives And Sleep Medicines: Combined use with benzodiazepines or sleep aids can cause dangerous drowsiness and slowed breathing.
• Warfarin: May increase the blood thinning effect and raise bleeding risk.
• Carbamazepine: May increase carbamazepine levels and the risk of its side effects.
• Other Paracetamol Containing Medicines: Taking together raises the risk of accidental paracetamol overdose and liver damage.

Risks and warnings

• Cardiac Risk: Overdose can cause dangerous heart rhythm disturbances, so never exceed the prescribed dose.
• Dependence: Prolonged use may lead to opioid dependence or tolerance.
• Liver Risk: High doses or long term use can cause liver damage due to the paracetamol component.
• Pregnancy And Breastfeeding: Use only if clearly advised by a doctor, since safety in pregnancy and breastfeeding is not well established.
• Driving And Machinery: May cause drowsiness or dizziness, so avoid driving until you know how the tablet affects you.
• Alcohol: Avoid alcohol while taking this medicine, as it raises the risk of sedation and liver toxicity.

Diagesic Tablet Side Effects

• Nausea
• Vomiting
• Dizziness
• Drowsiness
• Constipation
• Dry mouth
• Skin rash
• Stomach upset
• Irregular heartbeat
• Difficulty breathing
• Severe allergic reaction
• Liver damage with long term high dose use

Storage Conditions

• Store below 30°C in a cool, dry place
• Keep away from direct sunlight and moisture
• Keep out of reach of children
• Keep the tablet in its original blister pack until use