About Dioplus Tablet 10mg / 160mg
A fixed dose combination tablet that lowers high blood pressure by relaxing and widening blood vessels.
Dioplus Tablet Uses
- Treatment of high blood pressure (hypertension) in adults
- Used when blood pressure is not controlled by a single antihypertensive agent
- Helps reduce the risk of stroke and heart attack linked to uncontrolled hypertension
- Used in patients who need combination therapy for better blood pressure control
- Prescribed for hypertension with associated cardiovascular risk factors
Dioplus Tablet Benefits
- Combines two complementary mechanisms for stronger blood pressure control
- Amlodipine relaxes and widens blood vessels while Valsartan blocks a hormone that narrows them
- Single tablet reduces pill burden compared to taking two separate medicines
- Helps protect the heart and kidneys from long term effects of high blood pressure
- Suitable for long term maintenance therapy once blood pressure is stabilized
What Experts Say
Amlodipine belongs to the calcium channel blocker class. It works by blocking calcium from entering the smooth muscle cells lining blood vessel walls. This relaxes the vessels and widens them, which lowers the resistance the heart has to work against. Over time, this reduces systolic and diastolic blood pressure readings and eases strain on the heart.
Valsartan works through a different pathway. It belongs to the angiotensin receptor blocker class and blocks angiotensin II from binding to its receptors. Angiotensin II is a hormone that narrows blood vessels and triggers sodium and water retention. Blocking this action lowers blood pressure and reduces extra fluid volume that can raise it further.
Combining these two mechanisms addresses blood pressure from two separate pathways instead of one. Clinical guidelines support dual therapy when a single agent fails to bring blood pressure to target levels. This fixed dose combination also improves adherence, since patients take one tablet instead of two, which supports better long term blood pressure control.
Drug Class
- Calcium Channel Blocker
- Angiotensin II Receptor Blocker (ARB)
Dioplus Tablet 10mg / 160mg Uses in Urdu
- ہائی بلڈ پریشر کو کنٹرول کرنے کے لیے استعمال ہوتی ہے
- دل کے دورے اور فالج کے خطرے کو کم کرنے میں مددگار ہے
- ایسے مریضوں کے لیے تجویز کی جاتی ہے جن کا بلڈ پریشر ایک دوا سے کنٹرول نہ ہو
- خون کی نالیوں کو کھول کر دل پر دباؤ کم کرتی ہے
- گردوں اور دل کو بلند فشار خون کے مضر اثرات سے بچانے میں مدد دیتی ہے
Dioplus Tablet 10mg / 160mg formula
How to use Dioplus Tablet 10mg / 160mg?
- Take one tablet daily at the same time each day, with or without food.
- Swallow the tablet whole with a glass of water.
- Do not crush or chew the tablet.
- Continue taking it even if you feel well, since high blood pressure often has no symptoms.
- Do not stop the medicine suddenly without consulting your doctor.
Drug Interactions
- Potassium Sparing Diuretics: Combined use with drugs like spironolactone raises the risk of high potassium levels.
- NSAIDs: Medicines like ibuprofen and diclofenac can reduce the blood pressure lowering effect and affect kidney function.
- Other Antihypertensives: Combined use can have an additive effect and cause an excessive drop in blood pressure.
- Lithium: Valsartan can increase lithium levels in the blood, raising the risk of toxicity.
- CYP3A4 Inhibitors: Drugs like ketoconazole and erythromycin may increase amlodipine levels and side effects.
- Simvastatin: High doses combined with amlodipine may increase the risk of statin related muscle problems.
Risks and warnings
- Pregnancy: Not recommended during pregnancy, particularly the second and third trimester, due to risk of fetal harm.
- Kidney Impairment: Use with caution in patients with reduced kidney function, since dose adjustment may be needed.
- Liver Impairment: Caution advised in patients with liver disease.
- Low Blood Pressure: May cause hypotension, especially after the first dose or with dehydration.
- Hyperkalemia: Can raise potassium levels, particularly when combined with potassium sparing diuretics.
- Angioedema: Rare but serious swelling of the face, lips, or throat requires immediate medical attention.
Dioplus Tablet Side Effects
- Swelling in the ankles or feet
- Dizziness or lightheadedness
- Headache
- Fatigue
- Flushing
- Low blood pressure
- Nausea
- Palpitations
Storage Conditions
- Store below 30 degrees Celsius in a cool, dry place.
- Keep the tablet in its original blister pack until ready to use.
- Protect from direct sunlight and moisture.
- Keep out of reach of children.
- Do not store in the bathroom or near a sink.
