Dolace Tablet 37.5 / 325mg

About Dolace Tablet 37.5 / 325mg

Dolace Tablet 37.5 / 325mg Uses

• Relieves moderate to severe acute pain
• Manages post-operative and post-surgical pain
• Eases pain from injuries, fractures, and sprains
• Treats pain following dental procedures
• Controls musculoskeletal pain when weaker painkillers are not enough

Dolace Tablet 37.5 / 325mg Benefits

• Combines two pain relief mechanisms for a stronger effect
• Provides faster pain relief than paracetamol alone
• Allows a lower tramadol dose, reducing opioid related side effects
• Helps manage pain when NSAIDs are unsuitable

What Experts Say

Tramadol acts on opioid receptors in the brain and also affects serotonin and norepinephrine pathways, giving it two separate ways to control pain signals. Paracetamol adds its own pain relieving and fever reducing effect through a different pathway, so the combination often works better than either drug used alone at a similar dose.

Doctors generally reserve this combination for pain that has not responded well to paracetamol or NSAIDs used by themselves, such as after surgery, dental work, or a significant injury. Because tramadol is an opioid, prescribers assess a person's pain severity, medical history, and risk of dependence before recommending it, and they set clear limits on how long treatment should continue.

Extended or high dose use requires closer monitoring, since tramadol can affect breathing and interact with other sedating medicines. Doctors usually advise the shortest effective course, careful adherence to the prescribed schedule, and avoiding alcohol or other central nervous system depressants while taking it.

Drug Class

• Opioid Analgesic (Tramadol Component)
• Non-Opioid Analgesic and Antipyretic (Paracetamol Component)
• Centrally Acting Pain Reliever

Dolace Tablet 37.5 / 325mg formula

• Tramadol Hydrochloride + Paracetamol

Available forms

• Tablet

How to use Dolace Tablet 37.5 / 325mg?

• Take exactly as prescribed by your doctor
• Swallow the tablet whole with a glass of water
• Take with or without food as advised
• Do not take more than the prescribed daily dose
• Avoid alcohol while using this medicine
• Do not stop suddenly after regular use without medical advice

Drug Interactions

• MAOIs: Combining with monoamine oxidase inhibitors can cause dangerous serotonin syndrome.
• SSRIs and SNRIs: Increases the risk of serotonin syndrome when taken with these antidepressants.
• Other Opioids: Raises the risk of severe sedation and slowed breathing.
• Benzodiazepines: Combined use increases the risk of profound sedation and respiratory depression.
• Warfarin: May enhance the blood thinning effect and increase bleeding risk.
• Alcohol: Increases drowsiness and the risk of dangerous breathing problems.

Risks and warnings

• Dependence Risk: Tramadol can cause physical dependence and withdrawal symptoms if stopped suddenly after prolonged use.
• Breathing Problems: May slow or stop breathing, especially in the first days of treatment or with higher doses.
• Seizure Risk: Increases the risk of seizures, particularly at high doses or when combined with certain other medicines.
• Liver Damage: The paracetamol component can cause serious liver damage if the maximum daily dose is exceeded.
• Pregnancy: Not recommended during pregnancy due to risk of neonatal withdrawal symptoms.
• Elderly Patients: Requires lower doses and closer monitoring due to slower drug clearance.

Dolace Tablet 37.5 / 325mg Side Effects

• Nausea and vomiting
• Dizziness and drowsiness
• Dry mouth
• Excessive sweating
• Constipation
• Headache
• Confusion or mood changes
• Slowed or difficult breathing
• Seizures with high doses or prolonged use
• Serotonin syndrome when combined with other serotonergic medicines

Storage Conditions

• Store below 30°C in a cool, dry place away from sunlight
• Keep the tablets in the original blister pack until use
• Keep out of reach of children, given the opioid content
• Protect from moisture and excess heat
• Dispose of unused tablets safely rather than in household trash